Allosteric regulation of PKM2 allows cellular adaptation to different physiological states (Q43423481)

23 November 2017

title

Allosteric regulation of PKM2 allows cellular adaptation to different physiological states (English)

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23 November 2017

Dan Y Gui

1

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23 November 2017

Caroline A Lewis

series ordinal

2

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23 November 2017

Matthew G Vander Heiden

series ordinal

3

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23 November 2017

publication date

19 February 2013

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23 November 2017

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23 November 2017

volume

6

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23 November 2017

issue

263

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23 November 2017

page(s)

pe7

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Regulation of cancer cell metabolism

23 November 2017

cites work

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SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

21 January 2018

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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

21 January 2018

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The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate

21 January 2018

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

21 January 2018

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An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate

21 January 2018

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Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase

21 January 2018

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

21 January 2018

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Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact

21 January 2018

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1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase.

21 January 2018

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

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Identifiers

DOI

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23 November 2017

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