Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma (Q43560299)

24 November 2017

Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma (English)

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24 November 2017

3

L M Neckers

1 reference

24 November 2017

J S Isaacs

1

1 reference

PubMed ID

11279110

24 November 2017

S Saito

series ordinal

2

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PubMed ID

11279110

24 November 2017

language of work or name

English

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publication date

26 February 2001

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Journal of Biological Chemistry

24 November 2017

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24 November 2017

276

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24 November 2017

21

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24 November 2017

18497-18506

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

24 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Regulation of p53 function and stability by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M100638200

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Stress signals utilize multiple pathways to stabilize p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Identification of a cryptic nucleolar-localization signal in MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Evidence for a role of CRM1 in signal-mediated nuclear protein export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Elevated levels of wild-type p53 induced by radiolabeling of cells leads to apoptosis or sustained growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

MdmX protects p53 from Mdm2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100638200

21 January 2018

Identifiers

DOI

10.1074/JBC.M100638200

1 reference

24 November 2017

1 reference

PubMed ID

11279110