Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors (Q43966872)

28 November 2017

Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors (English)

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28 November 2017

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4

Elisabeth Brambilla

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28 November 2017

Béatrice Eymin

1

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28 November 2017

Sylvie Gazzeri

series ordinal

2

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28 November 2017

Christian Brambilla

series ordinal

3

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28 November 2017

language of work or name

English

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publication date

1 April 2002

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28 November 2017

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28 November 2017

21

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28 November 2017

17

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28 November 2017

2750-2761

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205359

28 November 2017

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cites work

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

The human protein p19ARF is not detected in hemopoietic human cell lines that abundantly express the alternative beta transcript of the p16INK4a/MTS1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Human ARF binds E2F1 and inhibits its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Physical and functional interaction between wild-type p53 and mdm2 proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Absence of mutations in the functional domains of the human MDM2 oncogene in non-small cell lung carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Induction of MDM2-P2 transcripts correlates with stabilized wild-type p53 in betel- and tobacco-related human oral cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Expression of mdm-2 protein in neoplastic, preneoplastic, and normal bronchial mucosa specimens: comparative study with p53 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

p53-independent role of MDM2 in TGF-beta1 resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

p53-independent functions of the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

mdm2: a bridge over the two tumour suppressors, p53 and Rb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

Abnormal expression of MDM-2 in breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

p53 genetic abnormalities and myc activation in human lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

Mechanisms of p16INK4A inactivation in non small-cell lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

A molecular and immunohistochemical study of the MDM2 protein isoforms and p53 gene product in bronchogenic carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

Expression profile of MDM-2 proteins in chronic lymphocytic leukemia and their clinical relevance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

Overexpression of p53 protein and MDM2 in papillary carcinomas of the thyroid: Correlations with clinicopathologic features

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

MDM2 mRNA expression is a favorable prognostic factor in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

Altered patterns of MDM2 and TP53 expression in human bladder cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

An immunochemical analysis of mdm2 expression in human breast cancer and the identification of a growth-regulated cross-reacting species p170

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205359

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205359

1 reference

Dimensions Publication ID

28 November 2017

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