Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. (Q44251907)

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English	Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.	scientific article

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Europe PubMed Central

1 December 2017

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation (English)

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12 May 2020

Alzheimer's disease

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Eliezer Masliah

6

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Eliezer Masliah

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12 May 2020

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Lennart Mucke

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12 May 2020

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Manuel Buttini

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12 May 2020

Gui-Qiu Yu

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12 May 2020

Kristina Shockley

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12 May 2020

Yadong Huang

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12 May 2020

Brian Jones

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12 May 2020

Margaret Mallory

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12 May 2020

Tracy Yeo

8

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12 May 2020

Frank M Longo

9

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12 May 2020

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publication date

1 December 2002

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Journal of Neuroscience

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12 May 2020

22

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12 May 2020

24

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12 May 2020

10539-10548

1 reference

Europe PubMed Central

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12 May 2020

Specific regional transcription of apolipoprotein E in human brain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors: A new class of psychotropic compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E and cognitive performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of brain activation in people at risk for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics and visual attention: selective deficits in healthy adult carriers of the epsilon 4 allele of the apolipoprotein E gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and processing of apolipoprotein E in human brain cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of APOE genotype on age at onset and progression of neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNS synaptogenesis promoted by glia-derived cholesterol

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgens protect against apolipoprotein E4-induced cognitive deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: a correlative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic cholinergic dysfunction in patients with dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration in the central nervous system of apoE-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E allele epsilon 4 is linked to increased deposition of the amyloid beta-peptide (A-beta) in cases with or without Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dementia with Lewy bodies versus pure Alzheimer disease: differences in cognition, neuropathology, cholinergic dysfunction, and synapse density.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 'amyloid cascade hypothesis' of AD: decoy or real McCoy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initiation and propagation stages of beta-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: a comparison with classic Alzheimer disease and normal aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron loss in APP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic neurodegenerative diseases: the human illness and transgenic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486146

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-24-10539.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758409&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758409&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758409&resulttype=core&format=json

12 May 2020

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