Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation (Q44319730)

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scientific article published in February 2003

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English	Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation	scientific article published in February 2003

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scholarly article

1 reference

Europe PubMed Central

1 December 2017

Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation (English)

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Europe PubMed Central

1 December 2017

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author name string

R Bortul

1

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P L Tazzari

2

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Europe PubMed Central

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A Cappellini

3

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Europe PubMed Central

1 December 2017

G Tabellini

4

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Europe PubMed Central

1 December 2017

A M Billi

5

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Europe PubMed Central

1 December 2017

R Bareggi

6

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Europe PubMed Central

1 December 2017

L Manzoli

7

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1 December 2017

L Cocco

8

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1 December 2017

A M Martelli

9

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1 December 2017

publication date

1 February 2003

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17

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2

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379-389

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1 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2402793

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Identification and characterization of a new member of the TNF family that induces apoptosis

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Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

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Safety and antitumor activity of recombinant soluble Apo2 ligand

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression

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Apoptosis signaling by death receptors.

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Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types

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Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells

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Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

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Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

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A novel receptor for Apo2L/TRAIL contains a truncated death domain

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

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Ten years of protein kinase B signalling: a hard Akt to follow

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The protein kinase B/Akt signalling pathway in human malignancy

1 reference

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Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance

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Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

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Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors

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TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

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Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.

1 reference

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Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

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PTEN: The down side of PI 3-kinase signalling.

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Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

1 reference

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

1 reference

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

1 reference

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

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Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies

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Induction of apoptosis by cancer chemotherapy.

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The biochemistry of apoptosis

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Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

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The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis.

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PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway.

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Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

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Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

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7 January 2021

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Interleukin-11 induces Th2 polarization of human CD4(+) T cells

1 reference

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7 January 2021

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Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1

1 reference

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Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.

1 reference

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7 January 2021

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Identifiers

10.1038/SJ.LEU.2402793

1 reference

Europe PubMed Central

1 December 2017

1 reference

Europe PubMed Central

1 December 2017

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