The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction (Q44324677)

2 December 2017

The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction (English)

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2 December 2017

4

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2 December 2017

Haiyan Wang

1

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2 December 2017

Pierre Maechler

2

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2 December 2017

Peter A Antinozzi

3

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2 December 2017

Kerstin A Hagenfeldt-Johansson

5

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2 December 2017

Anneli Bjorklund

6

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2 December 2017

Claes B Wollheim

7

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2 December 2017

language of work or name

English

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publication date

24 February 2003

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Journal of Biological Chemistry

2 December 2017

8

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based on heuristic

inferred from page(s)

published in

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2 December 2017

278

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2 December 2017

19

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2 December 2017

16622-16629

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

2 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Global and societal implications of the diabetes epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Regulation of fatty acid homeostasis in cells: novel role of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Fat in all the wrong places

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Metformin reverses fatty liver disease in obese, leptin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Rat glucokinase gene: structure and regulation by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

The uncoupling proteins, a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Modulation of RNA function by aminoglycoside antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

The biochemistry of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Shear stress activation of SREBP1 in endothelial cells is mediated by integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Metabolic coupling factors in pancreatic beta-cell signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Beta-cell adaptation and decompensation during the progression of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212488200

21 January 2018

Identifiers

DOI

10.1074/JBC.M212488200

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release_2cdhehj5jveaxoaocx3ugidvim

2 December 2017

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https://api.fatcat.wiki/v0/release/2cdhehj5jveaxoaocx3ugidvim

mapped directly with Wikidata item

24 November 2022

based on heuristic

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