The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses (Q44393406)

2 December 2017

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses (English)

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2 December 2017

1

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2 December 2017

2

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PubMed ID

22116087

2 December 2017

language of work or name

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25 November 2011

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Nature Reviews Immunology

2 December 2017

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2 December 2017

11

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2 December 2017

852-863

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2 December 2017

12

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The enemy within: keeping self-reactive T cells at bay in the periphery

2 December 2017

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

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TGF-beta influences the life and death decisions of T lymphocytes

21 January 2018

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The dichotomous role of IL-2: tolerance versus immunity.

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

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Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

21 January 2018

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Enhancement of antitumor immunity by CTLA-4 blockade

21 January 2018

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Principles and use of anti-CTLA4 antibody in human cancer immunotherapy

21 January 2018

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

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An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

21 January 2018

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CTLA4 gene polymorphism and autoimmunity

21 January 2018

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CD28, CTLA-4 and their ligands: who does what and to whom?

21 January 2018

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What's the difference between CD80 and CD86?

21 January 2018

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The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology

21 January 2018

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The B7/CD28 costimulatory family in autoimmunity

21 January 2018

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Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

21 January 2018

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CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

21 January 2018

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

21 January 2018

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The duration of antigenic stimulation determines the fate of naive and effector T cells.

21 January 2018

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A cellular calculus for signal integration by T cells

21 January 2018

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Differential T cell costimulatory requirements in CD28-deficient mice

21 January 2018

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Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40.

21 January 2018

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CTLA-4 can function as a negative regulator of T cell activation

21 January 2018

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

21 January 2018

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The interaction properties of costimulatory molecules revisited.

21 January 2018

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Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule

21 January 2018

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B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

21 January 2018

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Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation

21 January 2018

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Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

21 January 2018

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

21 January 2018

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Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.

21 January 2018

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Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

21 January 2018

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

21 January 2018

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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

21 January 2018

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FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

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Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

21 January 2018

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Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells.

21 January 2018

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Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

21 January 2018

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CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

21 January 2018

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CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

21 January 2018

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Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.

21 January 2018

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CTLA-4 control over Foxp3+ regulatory T cell function

21 January 2018

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CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation

21 January 2018

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CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice

21 January 2018

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CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

21 January 2018

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Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.

21 January 2018

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Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

21 January 2018

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How regulatory T cells work

21 January 2018

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CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

21 January 2018

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CTLA-4 ligation blocks CD28-dependent T cell activation

21 January 2018

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The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

21 January 2018

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

21 January 2018

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Molecular basis of T cell inactivation by CTLA-4

21 January 2018

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Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function

21 January 2018

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Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation

21 January 2018

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Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA-4 and its association with PI-3 kinase in intracellular compartments of T-cells

21 January 2018

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Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4

21 January 2018

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CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death

21 January 2018

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Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice

21 January 2018

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CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization

21 January 2018

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

21 January 2018

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The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase

21 January 2018

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Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

21 January 2018

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B7-independent inhibition of T cells by CTLA-4.

21 January 2018

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Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis

21 January 2018

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Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation.

21 January 2018

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1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.

21 January 2018

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The role of iron in T cell development and autoimmunity

21 January 2018

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The emerging role of CTLA-4 as an immune attenuator

21 January 2018

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Structural analysis of CTLA-4 function in vivo

21 January 2018

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CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function

21 January 2018

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Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

21 January 2018

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Reversal of the TCR stop signal by CTLA-4

21 January 2018

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TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice

21 January 2018

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Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

21 January 2018

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Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

21 January 2018

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Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.

21 January 2018

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Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.

21 January 2018

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

21 January 2018

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

21 January 2018

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Modulation of tryptophan catabolism by regulatory T cells.

21 January 2018

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Inhibition of T cell proliferation by macrophage tryptophan catabolism

21 January 2018

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Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase

21 January 2018

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CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86.

21 January 2018

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Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.

21 January 2018

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Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

21 January 2018

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HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism

21 January 2018

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Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction

21 January 2018

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1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity

21 January 2018

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Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

21 January 2018

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TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling

21 January 2018

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Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.

21 January 2018

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CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

21 January 2018

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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

21 January 2018

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

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A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

21 January 2018

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Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity

21 January 2018

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Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes

21 January 2018

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CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden

21 January 2018

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Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms

21 January 2018

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Biochemical analysis of CTLA-4 immunoreactive material from human blood

21 January 2018

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Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

21 January 2018

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Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells.

21 January 2018

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Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction

21 January 2018

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Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression

21 January 2018

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FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells

21 January 2018

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CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells.

21 January 2018

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Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system.

21 January 2018

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Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion

21 January 2018

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The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand

21 January 2018

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Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response

21 January 2018

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Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen

21 January 2018

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CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen

21 January 2018

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Costimulatory receptors in a teleost fish: typical CD28, elusive CTLA4.

21 January 2018

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The B7 family of immunoregulatory receptors: a comparative and evolutionary perspective

21 January 2018

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Thymocyte development is normal in CTLA-4-deficient mice

21 January 2018

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CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis

21 January 2018

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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Structure and dimerization of a soluble form of B7-1

21 January 2018

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TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells

21 January 2018

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The reverse stop-signal model for CTLA4 function.

21 January 2018

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CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4

21 January 2018

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Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered

21 January 2018

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Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation

21 January 2018

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Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

21 January 2018

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21 January 2018

12 December 2020

Foxp3-dependent programme of regulatory T-cell differentiation

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Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

21 January 2018

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Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

31 March 2020

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Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

31 March 2020

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Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

31 March 2020

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CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression

31 March 2020

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Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4

31 March 2020

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Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease

31 March 2020

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CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

31 March 2020

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CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice

31 March 2020

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12 December 2020

Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.

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12 December 2020

CTLA-4 regulates induction of anergy in vivo

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12 December 2020

Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous

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12 December 2020

Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2

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12 December 2020

Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells

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12 December 2020

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

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12 December 2020

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

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12 December 2020

Regulation of surface and intracellular expression of CTLA4 on mouse T cells

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12 December 2020

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4

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12 December 2020

Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells

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12 December 2020

Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo

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12 December 2020

Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression

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12 December 2020

CD28 is required for germinal center formation.

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12 December 2020

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

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12 December 2020

Activation of human T cells with superantigen (staphylococcal enterotoxin B) and CD28 confers resistance to apoptosis via CD95

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12 December 2020

Identifiers

DOI

10.1038/NRI3108

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2 December 2017

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PubMed ID

22116087