Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. (Q44419395)

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scientific article published in April 2003

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English	Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.	scientific article published in April 2003

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3 November 2019

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells (English)

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3 November 2019

James A. McCubrey

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William Blalock

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Richard A. Franklin

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3 November 2019

Linda S Steelman

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Linda S Steelman

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3 November 2019

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John G Shelton

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John T Lee

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Steven L Knapp

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Phillip W Moye

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Steven C Pohnert

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Amer M Mirza

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Martin McMahon

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3 November 2019

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1 April 2003

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3 November 2019

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3 November 2019

2478-2492

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3 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206321

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Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors

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Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

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PKB/AKT: functional insights from genetic models

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A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf

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p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

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Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

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21 January 2018

Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.

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21 January 2018

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.

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7 January 2021

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Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

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A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

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Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

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P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.

1 reference

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Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

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Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).

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Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells

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Regulation of Raf-1 activation and signalling by dephosphorylation

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7 January 2021

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Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

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Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

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Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

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Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

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Interactions between Ras and Raf: key regulatory proteins in cellular transformation

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Serine/threonine phosphorylation in cytokine signal transduction

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Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.

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Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

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Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

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Steroid receptor fusion proteins for conditional activation of Raf-MEK-ERK signaling pathway

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Negative regulation of Raf-1 by phosphorylation of serine 621.

1 reference

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7 January 2021

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Involvement of B-Raf in Ras-induced Raf-1 activation

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Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

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7 January 2021

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7 January 2021

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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

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Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

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7 January 2021

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