The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors (Q34241295)

31 July 2017

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title

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors (English)

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31 July 2017

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Weinstein-Oppenheimer CR

1

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31 July 2017

Blalock WL

2

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31 July 2017

Steelman LS

3

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31 July 2017

Chang F

4

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31 July 2017

McCubrey JA

5

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31 July 2017

publication date

1 December 2000

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Pharmacology & Therapeutics

31 July 2017

published in

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31 July 2017

volume

88

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31 July 2017

issue

3

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31 July 2017

page(s)

229-279

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Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis

31 July 2017

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

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7 January 2021

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Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. Effect of actinomycin D and antisense oligonucleotides

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7 January 2021

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7 January 2021

Raf-1 kinase, epidermal growth factor receptors, and mutant ras proteins in colonic carcinomas

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7 January 2021

WAF1, a potential mediator of p53 tumor suppression

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7 January 2021

Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes.

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7 January 2021

Isolation of MEK5 and differential expression of alternatively spliced forms

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7 January 2021

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7 January 2021

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7 January 2021

Src family protein tyrosine kinases and cellular signal transduction pathways

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7 January 2021

Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent

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7 January 2021

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

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7 January 2021

Modulation of cytotoxicity of chemotherapeutic drugs by activated H-ras

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7 January 2021

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7 January 2021

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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7 January 2021

Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells

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7 January 2021

RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)

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7 January 2021

v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells

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7 January 2021

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7 January 2021

Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Pharmaceutical research in molecular oncology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Farnesyltransferase inhibitors and anti-Ras therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Multiple ras effector pathways contribute to G(1) cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Antisense raf oligodeoxyribonucleotide is protected by liposomal encapsulation and inhibits Raf-1 protein expression in vitro and in vivo: implication for gene therapy of radioresistant cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

New treatments for breast cancer: breakthroughs for patient care or just steps in the right direction?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Association of K-ras mutations with p16 methylation in human colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

MAP kinase binds to the NH2-terminal activation domain of c-Myc

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mechanism of inhibition of Raf-1 by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mapping by chromosome sorting of several gene probes, including c-myc, to the derivative chromosomes of a 3;8 translocation associated with familial renal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-2-positive malignant cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Sulindac sulfide inhibits Ras signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Transcriptional regulation by extracellular signals: mechanisms and specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Functional analysis of a growth factor-responsive transcription factor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Competitive inhibition of MAP kinase activation by a peptide representing the alpha C helix of ERK.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activation of the MAP kinase pathway by the protein kinase raf

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Biochemical and biological analysis of Mek1 phosphorylation site mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Structural analysis of receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Overexpression of the c-erbB-2 protein in human breast tumor cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Oncogenes in head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Rat c-raf oncogene activation by a rearrangement that produces a fused protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Drug development train gathering steam

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Analysis of the ERK-stimulated ETS transcription factor ER81.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activation of ternary complex factor Elk-1 by MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Unscheduled expression of cyclins D1 and D3 in human tumour cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells☆☆☆

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Regulation of c-myc expression by Ras/Raf signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Actinomycin D as a novel SH2 domain ligand inhibits Shc/Grb2 interaction in B104-1-1 (neu*-transformed NIH3T3) and SAA (hEGFR-overexpressed NIH3T3) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

In vitro transcriptional activation of p21 promoter by p53

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

c-erbB-2 oncoprotein assay in ovarian carcinoma and its clinical correlation with prognostic factors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Different effects of various phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 activates MAP kinase-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

New functional activities for the p21 family of CDK inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Characterization of Raf-1 activation in mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 Is Activated during Mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Molecular and cellular biology of prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

DP and E2F proteins: coordinating transcription with cell cycle progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cytotoxicity and specificity of directed toxins composed of diphtheria toxin and the EGF-like domain of heregulin beta1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Abrogation of c-Raf expression induces apoptosis in tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The cell cycle and regulation of cancer cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

CK2alpha-protein phosphatase 2A molecular complex: possible interaction with the MAP kinase pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Tyrosine kinase inhibition: an approach to drug development

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Analysis of signaling protein kinases in human colon or colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Targets of p56(lck) activity in immature thymoblasts: stimulation of the Ras/Raf/MAPK pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

1 reference

7 January 2021

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Interactions between Ras and Raf: key regulatory proteins in cellular transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Serine/threonine phosphorylation in cytokine signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Biological consequences of a point mutation at codon 969 of the FMS gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Herceptin raises its sights beyond advanced breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

How should HER2 status be determined?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Overexpression of the oncogene c-erbB-2 (HER2/neu) in ovarian cancer: a new prognostic factor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

KSR stimulates Raf-1 activity in a kinase-independent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Regulation of protein kinase cascades by protein phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Bcl-x(S) anatagonizes the protective effects of Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Negative regulation of Raf-1 by phosphorylation of serine 621.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A B-cell line having chromosome 14 aberration at break band q11 derived from an adult T-cell leukemia patient.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Specific abnormalities of chromosome 14 in patients with acute type of adult T-cell leukemia/lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mechanisms regulating Raf-1 activity in signal transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mitogen-activated protein kinase and cytoskeleton in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Regulation of the cyclin E gene by transcription factor E2F1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cyclin-dependent regulation of G1 in mammalian fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Bcl-2 does not require Raf kinase activity for its death-protective function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phosphatases and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Signaling networks--do all roads lead to the same genes?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Epidermal growth factor induces cyclin D1 in a human prostate cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cytogenetic analysis and RAS mutations in primary myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Nerve growth factor receptor signaling in proliferation of normal adult rat chromaffin cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ras regulatory interactions: novel targets for anti-cancer intervention?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf revealed in life-or-death decisions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Angiogenesis induced by urothelial cells (HCV-29) and their v-ras and v-raf transfectants

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A Dominant Negative RAF-1 Mutant Prevents V-SRC-Induced Transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

N-myristoylation of a peptide substrate for Src converts it into an apparent slow-binding bisubstrate-type inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activated Raf-1 causes growth arrest in human small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Structure—Function Analysis of Bcl-2 Family Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activated protooncogenes in human lung tumors from smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Differential c-myc, c-jun, c-raf and p53 expression in squamous cell carcinoma of the head and neck: implication in drug and radioresistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

On the biotech pharm, a race to harvest new cancer cures

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bbeta with PDGF receptor and phosphorylation of SH2-Bbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

c-fos is required for malignant progression of skin tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Molecular abnormalities in lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The MAPK signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The function of steroid hormone receptors is inhibited by the hsp90-specific compound geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Synergistic increase in c-fos expression by simultaneous activation of the ras/raf/map kinase- and protein kinase A signaling pathways is mediated by the c-fos AP-1 and SRE sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Signal transduction of stress via ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Tumor suppression. Lessons in p16 from phylum Falconium

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

G1 phase progression: cycling on cue

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

1 reference

7 January 2021

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The STAT family of proteins in cytokine signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

An antibody reactive with domain 4 of the platelet-derived growth factor beta receptor allows BB binding while inhibiting proliferation by impairing receptor dimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Characterization of downstream Ras signals that induce alternative protease-dependent invasive phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Hyperexpression of mitogen-activated protein kinase in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Molecular pattern of ductal pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

1 reference

7 January 2021

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cyclins and breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Differentiation and growth modulation of myeloid leukemia cells by the protein kinase C activating agent bryostatin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Synergistic action of R-Ras and IGF-1 on Bcl-xL expression and caspase-3 inhibition in BaF3 cells: R-Ras and IGF-1 control distinct anti-apoptotic kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A dominant interfering Myb mutant causes apoptosis in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

KSR modulates signal propagation within the MAPK cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Role of c-kit receptor tyrosine kinase in the development, survival and neoplastic transformation of mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Targeting myeloid leukemia with a DT(390)-mIL-3 fusion immunotoxin: ex vivo and in vivo studies in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Complex formation between RAS and RAF and other protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-zeta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimens

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Expression patterns and transcript processing of ftt-1 and ftt-2, two C. elegans 14-3-3 homologues

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

1 reference

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7 January 2021

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Signal transduction pathways involving the Raf proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Analysis of the cyclin-dependent kinase inhibitors p18 and p19 in mantle-cell lymphoma and chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The interaction of Ras with GTPase-activating proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Endothelial apoptosis in Braf-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Reverse transcriptase polymerase chain reaction as a reliable method to detect epidermal growth factor receptor exon 2-7 gene deletion in human glioblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

The protein kinase KSR interacts with 14-3-3 protein and Raf.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phosphorylation of Raf by ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mapping GRB2, a signal transduction gene in the human and the mouse

1 reference

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7 January 2021

Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II

1 reference

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7 January 2021

Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cell cycle-regulated transcription in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900085-1

7 January 2021

Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit

1 reference

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7 January 2021

10.1016/S0163-7258(00)00085-1

Identifiers

DOI

1 reference

31 July 2017

1 reference