Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme (Q44466061)

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English	Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme (English)

1 reference

Europe PubMed Central

3 December 2017

4

1 reference

Europe PubMed Central

3 December 2017

author name string

Sabine Reither

1

1 reference

Europe PubMed Central

3 December 2017

Fuyang Li

2

1 reference

Europe PubMed Central

3 December 2017

Humaira Gowher

3

1 reference

Europe PubMed Central

3 December 2017

language of work or name

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publication date

1 June 2003

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Europe PubMed Central

3 December 2017

Journal of Molecular Biology

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Europe PubMed Central

3 December 2017

329

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Europe PubMed Central

3 December 2017

4

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Europe PubMed Central

3 December 2017

675-684

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Europe PubMed Central

3 December 2017

Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases

1 reference

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DNA methylation patterns and epigenetic memory

1 reference

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The role of DNA methylation in mammalian epigenetics

1 reference

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AdoMet-dependent methylation, DNA methyltransferases and base flipping

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DNA methylation in health and disease

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7 January 2021

Structure and function of DNA methyltransferases.

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7 January 2021

DNA methyltransferases

1 reference

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DNA methylation and chromatin modification.

1 reference

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7 January 2021

Molecular biology. Methylation talk between histones and DNA.

1 reference

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7 January 2021

Cytosine methylation and human cancer

1 reference

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7 January 2021

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

1 reference

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7 January 2021

The fundamental role of epigenetic events in cancer

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7 January 2021

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1 reference

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7 January 2021

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

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7 January 2021

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

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7 January 2021

Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites

1 reference

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7 January 2021

The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA

1 reference

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7 January 2021

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

1 reference

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7 January 2021

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

1 reference

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7 January 2021

In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b

1 reference

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7 January 2021

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.

1 reference

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7 January 2021

Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900509-6

7 January 2021

Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900509-6

7 January 2021

Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900509-6

7 January 2021

Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases

1 reference

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7 January 2021

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900509-6

7 January 2021

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

1 reference

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7 January 2021

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900509-6

7 January 2021

HhaI methyltransferase flips its target base out of the DNA helix

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900509-6

7 January 2021

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

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7 January 2021

The catalytic mechanism and structure of thymidylate synthase

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7 January 2021

Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

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7 January 2021

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7 January 2021

5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase

1 reference

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7 January 2021

Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

1 reference

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7 January 2021

The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA binding

1 reference

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7 January 2021

Sequence-specific and mechanism-based crosslinking of Dcm DNA cytosine-C5 methyltransferase of E. coli K-12 to synthetic oligonucleotides containing 5-fluoro-2'-deoxycytidine

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7 January 2021

DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe.

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7 January 2021

The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing

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7 January 2021

The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor

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Sequential order of target-recognizing domains in multispecific DNA-methyltransferases

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The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center

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DNA methylation and gene activity

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DNA methylation represses transcription in vivo.

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CpG methylation as a mechanism for the regulation of E2F activity

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Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites

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Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

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The 5-lipoxygenase promoter is regulated by DNA methylation

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Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences

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m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts

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10.1016/S0022-2836(03)00509-6

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Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

3 December 2017

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