The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex (Q44548884)

4 December 2017

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex (English)

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4 December 2017

transmembrane protein

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author

Julia Costa

5

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4 December 2017

Adam S Crystal

2

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author name string

Vanessa A Morais

1

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4 December 2017

Donald S Pijak

3

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4 December 2017

Dan Carlin

4

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4 December 2017

Virginia M-Y Lee

6

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4 December 2017

Robert W Doms

7

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4 December 2017

language of work or name

English

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publication date

12 August 2003

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Journal of Biological Chemistry

4 December 2017

8

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based on heuristic

inferred from page(s)

published in

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4 December 2017

278

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4 December 2017

44

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4 December 2017

43284-43291

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

4 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M305685200

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M305685200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

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Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

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Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Membrane topology of gamma-secretase component PEN-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Quality control in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Helical membrane protein folding, stability, and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Overexpression of nicastrin increases Aß production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305685200

21 January 2018

Identifiers

DOI

10.1074/JBC.M305685200

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4 December 2017

1 reference