Why must T cells be cross-reactive? (Q44666822)

5 December 2017

title

Why must T cells be cross-reactive? (English)

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5 December 2017

1

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5 December 2017

publication date

1 September 2012

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Nature Reviews Immunology

5 December 2017

published in

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5 December 2017

volume

12

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5 December 2017

issue

9

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5 December 2017

page(s)

669-677

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Ligand recognition by alpha beta T cell receptors

5 December 2017

cites work

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T cell receptor gene diversity and selection

31 March 2020

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T-cell antigen receptor genes and T-cell recognition

31 March 2020

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IMGT, the international ImMunoGeneTics information system.

31 March 2020

1 reference

How TCRs bind MHCs, peptides, and coreceptors

31 March 2020

1 reference

Conformational restraints and flexibility of 14-meric peptides in complex with HLA-B*3501.

31 March 2020

1 reference

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

31 March 2020

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THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

31 March 2020

1 reference

The somatic generation of immune recognition

31 March 2020

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A very high level of crossreactivity is an essential feature of the T-cell receptor

31 March 2020

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Specificity and degeneracy of T cells

31 March 2020

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Polyspecificity of T cell and B cell receptor recognition

31 March 2020

1 reference

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands

31 March 2020

1 reference

A direct estimate of the human alphabeta T cell receptor diversity

31 March 2020

1 reference

IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex

31 March 2020

1 reference

A uniquely high level of recombination at the HLA-B locus.

31 March 2020

1 reference

HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage

31 March 2020

1 reference

Impact of MHC class I diversity on immune control of immunodeficiency virus replication

31 March 2020

1 reference

In search of the 'missing self': MHC molecules and NK cell recognition

31 March 2020

1 reference

Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues

31 March 2020

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Control of mating preferences in mice by genes in the major histocompatibility complex

31 March 2020

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Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial

31 March 2020

1 reference

Population biology of antigen presentation by MHC class I molecules

31 March 2020

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HLA supertypes and supermotifs: a functional perspective on HLA polymorphism

31 March 2020

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Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis

31 March 2020

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Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

31 March 2020

1 reference

Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self

31 March 2020

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Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes

31 March 2020

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Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants

31 March 2020

1 reference

The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition

31 March 2020

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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

31 March 2020

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Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

31 March 2020

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T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

31 March 2020

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

31 March 2020

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A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

31 March 2020

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TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms

31 March 2020

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Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes

31 March 2020

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Disparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding Mechanism

31 March 2020

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Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

31 March 2020

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Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

31 March 2020

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A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

31 March 2020

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How a single T cell receptor recognizes both self and foreign MHC

31 March 2020

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A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

31 March 2020

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Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

31 March 2020

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A single autoimmune T cell receptor recognizes more than a million different peptides

31 March 2020

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A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160

31 March 2020

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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

31 March 2020

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Positive and negative selection of T cells

31 March 2020

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The repertoire of T cells shaped by a single MHC/peptide ligand.

31 March 2020

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T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

31 March 2020

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CD8 controls T cell cross-reactivity

31 March 2020

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Antigen arrays in T cell immunology

31 March 2020

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Exploring immunological specificity using synthetic peptide combinatorial libraries.

31 March 2020

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Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases

31 March 2020

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Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

31 March 2020

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Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells

31 March 2020

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Tricks with tetramers: how to get the most from multimeric peptide-MHC.

31 March 2020

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The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

31 March 2020

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Coreceptor CD8-driven modulation of T cell antigen receptor specificity.

31 March 2020

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CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

31 March 2020

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Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

31 March 2020

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Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

31 March 2020

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CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

31 March 2020

1 reference

No one is naive: the significance of heterologous T-cell immunity.

31 March 2020

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The history of the smallpox vaccine

31 March 2020

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The role of BCG in prevention of leprosy: a meta-analysis

31 March 2020

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CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses

31 March 2020

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Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein

31 March 2020

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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes.

31 March 2020

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Cross-reactivity between HLA-A2-restricted FLU-M1:58-66 and HIV p17 GAG:77-85 epitopes in HIV-infected and uninfected individuals

31 March 2020

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Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis

31 March 2020

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Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells

31 March 2020

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Heterologous T cell immunity in severe hepatitis C virus infection

31 March 2020

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Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

31 March 2020

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Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.

31 March 2020

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Molecular mimicry and autoimmunity.

31 March 2020

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Infection, mimics, and autoimmune disease

31 March 2020

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Selection of functional T cell receptor mutants from a yeast surface-display library

31 March 2020

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Directed evolution of human T-cell receptors with picomolar affinities by phage display.

31 March 2020

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Cutting edge: Evidence for a dynamically driven T cell signaling mechanism.

31 March 2020

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Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness

31 March 2020

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Human TCR-binding affinity is governed by MHC class restriction

31 March 2020

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Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

31 March 2020

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Kinetic proofreading in T-cell receptor signal transduction

31 March 2020

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Adoptive immunotherapy for cancer: harnessing the T cell response

31 March 2020

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Cancer regression in patients after transfer of genetically engineered lymphocytes

31 March 2020

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Monoclonal TCR-redirected tumor cell killing.

31 March 2020

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Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

31 March 2020

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Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination

31 March 2020

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Quantitating T cell cross-reactivity for unrelated peptide antigens

31 March 2020

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Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

31 March 2020

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Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

31 March 2020

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Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

31 March 2020

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The shaping of T cell receptor recognition by self-tolerance

31 March 2020

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Molecular mimicry and immune-mediated diseases

31 March 2020

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12 December 2020

Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases

1 reference

12 December 2020

Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity

1 reference

12 December 2020

CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C-) to TCR/CD8 signaling in response to antigen.

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12 December 2020

Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules

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12 December 2020

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

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12 December 2020

Identifiers

DOI

10.1038/NRI3279

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release_tfjkowes3bbhrkq22i45xocz64

5 December 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/tfjkowes3bbhrkq22i45xocz64

24 November 2022

mapped directly with Wikidata item

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