The cell biology of Alzheimer's disease: uncovering the secrets of secretases (Q34398091)

1 August 2017

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title

The cell biology of Alzheimer's disease: uncovering the secrets of secretases (English)

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1 August 2017

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4

Haass C

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1 August 2017

Walter J

1

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1 August 2017

Kaether C

series ordinal

2

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1 August 2017

Steiner H

series ordinal

3

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1 August 2017

language of work or name

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1 October 2001

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Current Opinion in Neurobiology

1 August 2017

published in

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1 August 2017

volume

11

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1 August 2017

issue

5

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1 August 2017

page(s)

585-590

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Alzheimer's disease: genes, proteins, and therapy

1 August 2017

cites work

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7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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7 January 2021

Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins.

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7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

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7 January 2021

Amyloid fibrillogenesis: themes and variations

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7 January 2021

Amyloid diseases: abnormal protein aggregation in neurodegeneration

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Intramembrane proteolysis by presenilins

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Expression analysis of BACE2 in brain and peripheral tissues

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Phosphorylation regulates intracellular trafficking of beta-secretase

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Notch signaling: from the outside in

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

The multiple paradoxes of presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Gamma -secretase inhibitors repress thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900253-1

7 January 2021

10.1016/S0959-4388(00)00253-1

Identifiers

DOI

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1 August 2017

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