Stable and functional lymphoid reconstitution in artemis-deficient mice following lentiviral artemis gene transfer into hematopoietic stem cells. (Q44856050)

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scientific article published on 17 June 2008

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English	Stable and functional lymphoid reconstitution in artemis-deficient mice following lentiviral artemis gene transfer into hematopoietic stem cells.	scientific article published on 17 June 2008

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9 January 2020

Stable and functional lymphoid reconstitution in artemis-deficient mice following lentiviral artemis gene transfer into hematopoietic stem cells (English)

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9 January 2020

Alexandrine Garrigue

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Corinne de Chappedelaine

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Jean-Pierre de Villartay

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Marina Cavazzana

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Pauline Soulas-Sprauel

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9 January 2020

Pierre Charneau

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Pierre Charneau

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9 January 2020

Fatine Benjelloun

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Johanna Blondeau

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Annick Lim

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Michele Malassis-Séris

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Daniel Stockholm

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Julia Hauer

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Julie Rivière

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Marc Le Lorc'h

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Nicole Brousse

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9 January 2020

Frederique Pâques

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9 January 2020

Anne Galy

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9 January 2020

Alain Fischer

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9 January 2020

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17 June 2008

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9 January 2020

Molecular Therapy

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9 January 2020

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9 January 2020

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9 January 2020

1490-1499

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9 January 2020

Severe combined immunodeficiencies (SCID)

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RAG mutations in human B cell-negative SCID.

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

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Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

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Damaging-agent sensitivity of Artemis-deficient cell lines

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Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle.

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