Defective DNA repair and increased genomic instability in Artemis-deficient murine cells (Q28513655)

25 January 2017

title

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells (English)

1 reference

25 January 2017

main subject

DNA cross-link repair 1C

1 reference

GOA release 2020-03-11

JoAnn Sekiguchi

10

0 references

David B. Lombard

object named as

David Lombard

3

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author name string

Sean Rooney

1

1 reference

25 January 2017

Frederick W. Alt

2

1 reference

25 January 2017

Scott Whitlow

4

1 reference

25 January 2017

Mark Eckersdorff

5

1 reference

25 January 2017

James Fleming

6

1 reference

25 January 2017

Sebastian Fugmann

7

1 reference

25 January 2017

David O. Ferguson

8

1 reference

25 January 2017

David G. Schatz

9

1 reference

25 January 2017

language of work or name

English

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publication date

3 March 2003

1 reference

Journal of Experimental Medicine

25 January 2017

published in

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25 January 2017

volume

197

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25 January 2017

issue

5

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25 January 2017

page(s)

553–565

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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

25 January 2017

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19 March 2017

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

19 March 2017

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19 March 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?

29 September 2017

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Ku86 is essential in human somatic cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

29 September 2017

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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

29 September 2017

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29 September 2017

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29 September 2017

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DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

29 September 2017

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Gamma-irradiation directly affects the formation of coding joints in SCID cell lines

29 September 2017

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Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

29 September 2017

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

29 September 2017

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DNA hairpin opening mediated by the RAG1 and RAG2 proteins

29 September 2017

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Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

29 September 2017

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29 September 2017

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A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency

29 September 2017

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Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

29 September 2017

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Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

29 September 2017

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29 September 2017

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Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

21 January 2018

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P nucleotides, hairpin DNA and V(D)J joining: making the connection

21 January 2018

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A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p

21 January 2018

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12 December 2020

DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice.

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Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints

27 November 2018

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12 December 2020

T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

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12 December 2020

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

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12 December 2020

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

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12 December 2020

Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts

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12 December 2020

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement

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Identifiers

DOI

10.1084/JEM.20021891

1 reference

1 reference

1 reference

1 reference