Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters. (Q45170299)

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scientific article published on 27 November 2013

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English	Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters.	scientific article published on 27 November 2013

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1 March 2020

Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters (English)

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1 March 2020

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Il Seong Nam-Goong

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author name string

T H Tu

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C-S Kim

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J-H Kang

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C W Nam

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E S Kim

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Y I Kim

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J I Choi

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T Kawada

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J H Yoon Park

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M-S Choi

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R Yu

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27 November 2013

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International Journal of Obesity

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1075-1082

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8

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1 March 2020

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

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Adipocytokines and the metabolic complications of obesity

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The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity

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Obesity is associated with macrophage accumulation in adipose tissue

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Inflammation and insulin resistance

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A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha

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The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.

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Characterization of herpes virus entry mediator as a factor linked to obesity

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CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications

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Effects of obesity and weight loss on soluble CD40L levels

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CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses

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Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders

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CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction

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CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice.

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Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis.

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CD137-CD137 Ligand Interactions in Inflammation

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Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis.

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21 January 2018

Positive correlation between CD137 expression and complex stenosis morphology in patients with acute coronary syndromes.

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21 January 2018

Clinical implications of elevated serum soluble CD137 levels in patients with acute coronary syndrome

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21 January 2018

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

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Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; Internat

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Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation

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The soluble interleukin 6 receptor: mechanisms of production and implications in disease

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Induction of lethal graft-versus-host disease by anti-CD137 monoclonal antibody in mice prone to chronic graft-versus-host disease

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21 January 2018

Plasma soluble tumour necrosis factor-alpha receptor 2 is elevated in obesity: specific contribution of visceral adiposity

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IL-6 and its receptors in coronary artery disease and acute myocardial infarction.

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21 January 2018

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

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21 January 2018

Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies.

1 reference

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21 January 2018

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo

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21 January 2018

Interleukin 6 and its receptor: ten years later

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21 January 2018

The metabolic syndrome in the asian population

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21 January 2018

Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia

1 reference

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21 January 2018

T-ing up inflammation in fat

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21 January 2018

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

1 reference

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12 December 2020

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CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

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Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications

1 reference

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12 December 2020

based on heuristic

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Canadian global village reality: anthropometric surrogate cutoffs and metabolic abnormalities among Canadians of East Asian, South Asian, and European descent

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

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CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced levels of soluble and membrane-bound CD137 levels in patients with acute coronary syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

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Relationships of soluble APO-1 (Fas/CD95) concentrations, obesity, and serum lipid parameters in healthy adults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

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inferred from PubMed ID database lookup

Circulating levels of TNF? and TNF receptor superfamily members in lymphoid neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

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inferred from PubMed ID database lookup

Soluble receptors in human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

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inferred from PubMed ID database lookup

CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB/4-1BBL interaction promotes obesity-induced adipose inflammation by triggering bidirectional inflammatory signaling in adipocytes/macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24281650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/IJO.2013.222

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1 March 2020

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1 March 2020

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