Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation. (Q45188895)

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6 January 2020

title

Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation (English)

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6 January 2020

author name string

J Glen Newell

series ordinal

1

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6 January 2020

Ross A McDevitt

series ordinal

2

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6 January 2020

Cynthia Czajkowski

series ordinal

3

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6 January 2020

language of work or name

English

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publication date

1 December 2004

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6 January 2020

published in

Journal of Neuroscience

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6 January 2020

volume

24

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6 January 2020

issue

50

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6 January 2020

page(s)

11226-11235

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Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer

6 January 2020

cites work

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12 December 2020

Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand.

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Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation

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Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine

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The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain

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Mapping the conformational wave of acetylcholine receptor channel gating

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Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor

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12 December 2020

Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study

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12 December 2020

Allosteric modulation in spontaneously active mutant gamma-aminobutyric acid(A) receptors [corrected].

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12 December 2020

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

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12 December 2020

Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.

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12 December 2020

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

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12 December 2020

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

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12 December 2020

Subunit arrangement of gamma-aminobutyric acid type A receptors

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12 December 2020

GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions

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12 December 2020

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites

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12 December 2020

Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions

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12 December 2020

Anxiety over GABA(A) receptor structure relieved by AChBP.

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12 December 2020

Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

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12 December 2020

Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening

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12 December 2020

Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement

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12 December 2020

Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism

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12 December 2020

Coupling of agonist binding to channel gating in the GABA(A) receptor

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12 December 2020

The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating

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12 December 2020

Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.

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12 December 2020

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

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12 December 2020

Structure and gating mechanism of the acetylcholine receptor pore

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12 December 2020

Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site

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12 December 2020

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

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12 December 2020

An arginine involved in GABA binding and unbinding but not gating of the GABA(A) receptor.

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12 December 2020

Gating dynamics of the acetylcholine receptor extracellular domain.

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12 December 2020

Cys-loop receptors: new twists and turns

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12 December 2020

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.

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12 December 2020

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain

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12 December 2020

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites

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12 December 2020

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

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12 December 2020

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family

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12 December 2020

Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

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12 December 2020

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

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12 December 2020

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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12 December 2020

Single channel currents activated by gamma-aminobutyric acid, muscimol, and (-)-pentobarbital in cultured mouse spinal neurons

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12 December 2020

GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

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12 December 2020

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms

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12 December 2020

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1 reference

12 December 2020

Chloride Channel Expression with the Tandem Construct of α6-β2 GABAA Receptor Subunit Requires a Monomeric Subunit of α6 or γ2

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12 December 2020

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

1 reference

12 December 2020

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

12 December 2020

Do salt bridges stabilize proteins? A continuum electrostatic analysis.

1 reference

12 December 2020

Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA.

1 reference

12 December 2020

The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site.

1 reference

12 December 2020

Stoichiometry of a recombinant GABAA receptor.

1 reference

12 December 2020

Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors

1 reference

12 December 2020

Anionic residue in the alpha-subunit of the nicotinic acetylcholine receptor contributing to subunit assembly and ligand binding

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12 December 2020

Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes.

1 reference

12 December 2020

Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor

1 reference

12 December 2020

Stoichiometry and assembly of a recombinant GABAA receptor subtype.

1 reference

12 December 2020

Mutations in different functional domains of the human muscle acetylcholine receptor alpha subunit in patients with the slow-channel congenital myasthenic syndrome

1 reference

12 December 2020

Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits.

1 reference

12 December 2020

Substitutions of the highly conserved M2 leucine create spontaneously opening rho1 gamma-aminobutyric acid receptors.

1 reference

12 December 2020

State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit

1 reference

12 December 2020

Substituted-cysteine accessibility method

1 reference

12 December 2020

Selective labeling of neurotransmitter transporters at the cell surface.

1 reference

12 December 2020

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

12 December 2020

10.1523/JNEUROSCI.3746-04.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15601928%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15601928%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

15601928

1 reference