Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease. (Q45307199)

PubMed publication ID

18077673

11 December 2017

title

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease (English)

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11 May 2020

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4

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11 May 2020

Lynn A Raymond

5

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11 May 2020

author name string

Herman B Fernandes

1

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11 May 2020

Kenneth G Baimbridge

2

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11 May 2020

John Church

3

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11 May 2020

language of work or name

English

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publication date

1 December 2007

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PubMed publication ID

18077673

11 December 2017

published in

Journal of Neuroscience

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11 May 2020

volume

27

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11 May 2020

issue

50

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11 May 2020

page(s)

13614-13623

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High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations

11 May 2020

cites work

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12 December 2020

Glutamate-induced neuron death requires mitochondrial calcium uptake

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12 December 2020

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

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12 December 2020

Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels

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12 December 2020

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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12 December 2020

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

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12 December 2020

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

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12 December 2020

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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12 December 2020

Transcriptional dysregulation in Huntington's disease

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12 December 2020

Assessment of mitochondrial polarization status in living cells based on analysis of the spatial heterogeneity of rhodamine 123 fluorescence staining

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12 December 2020

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

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12 December 2020

Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation.

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12 December 2020

Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity

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12 December 2020

Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus

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12 December 2020

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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12 December 2020

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

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12 December 2020

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

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12 December 2020

Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene

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12 December 2020

NMDA receptor function in mouse models of Huntington disease

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12 December 2020

Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation

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12 December 2020

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

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12 December 2020

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

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12 December 2020

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

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12 December 2020

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

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12 December 2020

Changes in mitochondrial status associated with altered Ca2+ homeostasis in aged cerebellar granule neurons in brain slices.

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12 December 2020

Activation of NR1/NR2B NMDA receptors.

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12 December 2020

In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.

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12 December 2020

Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.

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12 December 2020

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

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12 December 2020

Increased susceptibility of striatal mitochondria to calcium-induced permeability transition

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12 December 2020

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

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12 December 2020

Rigid and akinetic forms of Huntington's chorea

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12 December 2020

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

1 reference

12 December 2020

Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity

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12 December 2020

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

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12 December 2020

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

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12 December 2020

Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.

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12 December 2020

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

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12 December 2020

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

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12 December 2020

Ca2+-induced permeability transition in human lymphoblastoid cell mitochondria from normal and Huntington's disease individuals.

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12 December 2020

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

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12 December 2020

Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking

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12 December 2020

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

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12 December 2020

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

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12 December 2020

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

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12 December 2020

Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.

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12 December 2020

Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.

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12 December 2020

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

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12 December 2020

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

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12 December 2020

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

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12 December 2020

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.

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12 December 2020

Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones

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12 December 2020

Neuropathological classification of Huntington's disease

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12 December 2020

Juvenile Huntington disease

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12 December 2020

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors

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12 December 2020

GABA synapses formed in vitro by local axon collaterals of nucleus accumbens neurons

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12 December 2020

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

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12 December 2020

The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain

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12 December 2020

Mitochondrial dysfunction is a primary event in glutamate neurotoxicity

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12 December 2020

The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size

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12 December 2020

Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators

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12 December 2020

The effects of artificial calcium buffers on calcium responses and glutamate-mediated excitotoxicity in cultured hippocampal neurons

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12 December 2020

Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.

1 reference

12 December 2020

10.1523/JNEUROSCI.3455-07.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673605&resulttype=core&format=json

11 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673605&resulttype=core&format=json

11 May 2020

PubMed publication ID

18077673

1 reference