Transcriptional regulation by RUNX2 (Q45316819)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8878166)

Language	Label	Description	Also known as
English	Transcriptional regulation by RUNX2	An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8878166)

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instance of

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Generic Transcription Pathway

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https://identifiers.org/reactome:R-HSA-8878166

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Regulation of RUNX2 expression and activity

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RUNX2 regulates bone development

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RUNX2 regulates genes involved in cell migration

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RUNX2 regulates genes involved in differentiation of myeloid cells

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RUNX2 binds TWIST1,(TWIST2)

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CDK4 phosphorylates RUNX2

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RUNX2 binds CDKN1A gene promoter

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CDK1 phosphorylates RUNX2

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CDKN1A gene expression is inhibited by RUNX2

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PPM1D dephosphorylates RUNX2

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RUNX2 binds BAX gene promoter

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BAX gene expression is stimulated by RUNX2

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The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development

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Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

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Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST

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Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

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Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

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Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene

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Role of RUNX2 in Breast Carcinogenesis

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The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen

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A twist code determines the onset of osteoblast differentiation

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Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication

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Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells

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Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity

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The RUNX family: developmental regulators in cancer

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ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway

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Runx2 is expressed in human glioma cells and mediates the expression of galectin-3.

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Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation

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Cbfbeta interacts with Runx2 and has a critical role in bone development

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Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis

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Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

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Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

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Mutations in the RUNX2 gene in patients with cleidocranial dysplasia

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Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

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Dominance of SOX9 function over RUNX2 during skeletogenesis

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Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice

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Building strong bones: molecular regulation of the osteoblast lineage

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Developmental pathways hijacked by osteosarcoma

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Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors

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Cleidocranial dysplasia and RUNX2-clinical phenotype-genotype correlation

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RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors

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Transcriptional control of skeletogenesis

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

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RUNX2 promotes breast cancer bone metastasis by increasing integrin α5-mediated colonization

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Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform

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Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues

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Core-binding factor beta interacts with Runx2 and is required for skeletal development

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GALECTIN-3 expression in differentiating human myeloid cells

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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

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8 July 2022

Identifiers

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8 July 2022

Transcriptional regulation by RUNX2 (Q45316819)

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Transcriptional regulation by RUNX2 (Q45316819)

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