Building strong bones: molecular regulation of the osteoblast lineage (Q37970567)

26 August 2017

Building strong bones: molecular regulation of the osteoblast lineage (English)

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26 August 2017

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Fanxin Long

1

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26 August 2017

22 December 2011

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Nature Reviews Molecular Cell Biology

26 August 2017

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26 August 2017

13

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26 August 2017

27-38

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26 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrm3254

26 August 2017

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Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

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31 March 2020

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The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

31 March 2020

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Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

31 March 2020

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Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest

31 March 2020

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

31 March 2020

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

31 March 2020

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Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

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Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

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Rb regulates fate choice and lineage commitment in vivo

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Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function

31 March 2020

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Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

31 March 2020

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The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development

31 March 2020

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A twist code determines the onset of osteoblast differentiation

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Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2

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Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

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Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.

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Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

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Mutations in NOTCH1 cause aortic valve disease

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Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

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Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

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Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

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Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

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p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

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NFAT and Osterix cooperatively regulate bone formation

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31 March 2020

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FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice

31 March 2020

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31 March 2020

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Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation

31 March 2020

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The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

31 March 2020

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A common enzyme connects notch signaling and Alzheimer's disease

31 March 2020

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

31 March 2020

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

31 March 2020

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

31 March 2020

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31 March 2020

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31 March 2020

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Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

31 March 2020

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Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

31 March 2020

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Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone

31 March 2020

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Notch inhibits osteoblast differentiation and causes osteopenia

31 March 2020

1 reference

Dimorphic effects of Notch signaling in bone homeostasis.

31 March 2020

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Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent

31 March 2020

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Notch signaling contributes to the pathogenesis of human osteosarcomas

31 March 2020

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New aspects of Wnt signaling pathways in higher vertebrates

31 March 2020

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A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

31 March 2020

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Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

31 March 2020

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31 March 2020

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High bone density due to a mutation in LDL-receptor-related protein 5

31 March 2020

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

31 March 2020

1 reference

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

31 March 2020

1 reference

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

31 March 2020

1 reference

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

31 March 2020

1 reference

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

31 March 2020

1 reference

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

31 March 2020

1 reference

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

31 March 2020

1 reference

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

31 March 2020

1 reference

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

31 March 2020

1 reference

Regulation of osteoblastogenesis and bone mass by Wnt10b

31 March 2020

1 reference

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

31 March 2020

1 reference

Lrp5 functions in bone to regulate bone mass

31 March 2020

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

31 March 2020

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

31 March 2020

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Essential role of beta-catenin in postnatal bone acquisition

31 March 2020

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Genetic analysis of Lrp5 function in osteoblast progenitors.

31 March 2020

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Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5

31 March 2020

1 reference

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

31 March 2020

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Efficacy of serotonin inhibition in mouse models of bone loss

31 March 2020

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Sequential roles of Hedgehog and Wnt signaling in osteoblast development

31 March 2020

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Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

31 March 2020

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Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

31 March 2020

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Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

31 March 2020

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Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

31 March 2020

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Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation

31 March 2020

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Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

31 March 2020

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A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

31 March 2020

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Inhibition of adipogenesis by Wnt signaling

31 March 2020

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Control of bone formation by the serpentine receptor Frizzled-9

31 March 2020

1 reference

Specificity and versatility in tgf-beta signaling through Smads

31 March 2020

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Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

31 March 2020

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BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

31 March 2020

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BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

31 March 2020

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Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.

31 March 2020

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Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.

31 March 2020

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Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling

31 March 2020

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Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

31 March 2020

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Smad4 is required for maintaining normal murine postnatal bone homeostasis

31 March 2020

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Bone morphogenetic protein-3 is a negative regulator of bone density

31 March 2020

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BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

31 March 2020

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Functional evolutionary history of the mouse Fgf gene family

31 March 2020

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Cellular signaling by fibroblast growth factor receptors

31 March 2020

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FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

31 March 2020

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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

31 March 2020

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FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate

31 March 2020

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FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

31 March 2020

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Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation

31 March 2020

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Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

31 March 2020

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A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis.

31 March 2020

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Defective bone mineralization and osteopenia in young adult FGFR3-/- mice

31 March 2020

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The mature osteoblast phenotype is characterized by extensive plasticity

31 March 2020

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Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

31 March 2020

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Leptin regulates bone formation via the sympathetic nervous system

31 March 2020

1 reference

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

31 March 2020

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Skeletal phenotype of the leptin receptor-deficient db/db mouse

31 March 2020

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Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

31 March 2020

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Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo

31 March 2020

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Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo

31 March 2020

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Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration

31 March 2020

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The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone

31 March 2020

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Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation

31 March 2020

1 reference

The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis

31 March 2020

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Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling

31 March 2020

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TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation

31 March 2020

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Growth hormone, insulin-like growth factors, and the skeleton

31 March 2020

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Mode of growth hormone action in osteoblasts.

31 March 2020

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Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

31 March 2020

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Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

31 March 2020

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Suppressive function of androgen receptor in bone resorption

31 March 2020

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Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model

31 March 2020

1 reference

A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice

31 March 2020

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Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

31 March 2020

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Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone

31 March 2020

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Stromal stem cells: marrow-derived osteogenic precursors

31 March 2020

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12 December 2020

Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo.

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12 December 2020

A cytological and histochemical study of bone and cartilage formation in the rat.

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12 December 2020

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

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12 December 2020

The IIIc alternative of Fgfr2 is a positive regulator of bone formation.

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12 December 2020

THE FINE STRUCTURE OF BONE CELLS.

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12 December 2020

Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area.

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12 December 2020

The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen

1 reference

12 December 2020

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

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12 December 2020

Identifiers

DOI

10.1038/NRM3254

1 reference

PubMed ID

22189423

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22189423