Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma. (Q45358316)

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scientific article published in October 2012

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English	Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.	scientific article published in October 2012

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29 January 2020

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma (English)

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Europe PubMed Central

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29 January 2020

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Hepatitis B virus

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Hang Li

1

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29 January 2020

Ke Wu

2

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29 January 2020

Kaixiong Tao

3

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29 January 2020

Qichang Zheng

5

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29 January 2020

Xiaoming Lu

6

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29 January 2020

Jun Liu

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29 January 2020

Liang Shi

8

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29 January 2020

Chuanqiao Liu

9

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29 January 2020

Weiping Zou

11

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29 January 2020

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1 October 2012

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29 January 2020

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29 January 2020

56

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29 January 2020

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29 January 2020

1342-1351

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29 January 2020

Hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FHEP.25777

21 January 2018

Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.

1 reference

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Tumor-infiltrating lymphocytes and hepatocellular carcinoma: pathology and clinical management

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Human TH17 cells are long-lived effector memory cells.

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Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

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FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis.

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B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

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Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

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Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma.

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Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

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Regulatory T cells, tumour immunity and immunotherapy

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Inhibitory B7-family molecules in the tumour microenvironment

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Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.

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Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions

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Regulatory T cells are associated with post-cryoablation prognosis in patients with hepatitis B virus-related hepatocellular carcinoma

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Tumor-specific Th17-polarized cells eradicate large established melanoma

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T helper 17 cells promote cytotoxic T cell activation in tumor immunity

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21 January 2018

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

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21 January 2018

Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease

1 reference

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21 January 2018

Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

1 reference

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21 January 2018

Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance

1 reference

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21 January 2018

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

1 reference

https://api.crossref.org/works/10.1002%2FHEP.25777

21 January 2018

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

1 reference

https://api.crossref.org/works/10.1002%2FHEP.25777

21 January 2018

Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.25777

21 January 2018

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

1 reference

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21 January 2018

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

1 reference

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21 January 2018

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

1 reference

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21 January 2018

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

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21 January 2018

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

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21 January 2018

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

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21 January 2018

Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion

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Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

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Reversible senescence in human CD4+CD45RA+CD27- memory T cells.

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Dual biological effects of the cytokines interleukin-10 and interferon-γ.

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Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury

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Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

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Interferon γ limits the effectiveness of melanoma peptide vaccines

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Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients

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The immunosuppressive tumor microenvironment in hepatocellular carcinoma

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