Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysis. (Q45929037)

17 December 2017

title

Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysis. (English)

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17 December 2017

author name string

Caitlin E Cassidy

series ordinal

1

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17 December 2017

William N Setzer

series ordinal

2

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17 December 2017

publication date

15 July 2009

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17 December 2017

Journal of Molecular Modeling

published in

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17 December 2017

volume

16

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17 December 2017

issue

2

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17 December 2017

page(s)

311-326

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17 December 2017

Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

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Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations

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First structural evidence of a specific inhibition of phospholipase A2 by alpha-tocopherol (vitamin E) and its implications in inflammation: crystal structure of the complex formed between phospholipase A2 and alpha-tocopherol at 1.8 A resolution

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12 December 2020

Aromatase inhibitors in the treatment of breast cancer.

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Flavonoids from two Lonchocarpus species of the Yucatan Peninsula

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Role of ornithine decarboxylase in epidermal tumorigenesis

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Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution

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12 December 2020

Reactive oxygen species in tumor progression

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12 December 2020

Phospholipases A2 in ras-transfected fibroblasts

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12 December 2020

Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion

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12 December 2020

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

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Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site

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Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

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Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines

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12 December 2020

MolDock: a new technique for high-accuracy molecular docking

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Flavonoids of Lonchocarpus montanus A.M.G. Azevedo and biological activity

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12 December 2020

Inhibitory effects of flavonoids on xanthine oxidase.

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12 December 2020

Ornithine decarboxylase activity is critical for cell transformation

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The binding of xanthone derivatives to transthyretin.

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12 December 2020

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

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12 December 2020

Antioxidant activity, cytotoxicity, and DNA information of Glossogyne tenuifolia

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12 December 2020

Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.

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12 December 2020

Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

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12 December 2020

Flavonoids: Promising anticancer agents

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12 December 2020

Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes

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12 December 2020

Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain

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12 December 2020

Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells

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12 December 2020

Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives.

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12 December 2020

Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution

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12 December 2020

Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest

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12 December 2020

Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells

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12 December 2020

Structural Basis for Bile Salt Inhibition of Pancreatic Phospholipase A2

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12 December 2020

The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

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12 December 2020

Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead

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12 December 2020

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

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12 December 2020

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

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12 December 2020

A 3D linear solvation energy model to quantify the affinity of flavonoid derivatives toward P-glycoprotein

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12 December 2020

Antiproliferative activity of flavonoids on several cancer cell lines

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12 December 2020

Screening of herbal constituents for aromatase inhibitory activity

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12 December 2020

Crystal structure of human cytochrome P450 2C9 with bound warfarin

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12 December 2020

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells

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12 December 2020

Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.

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12 December 2020

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12 December 2020

Analysis and quantitation of rotenoids and flavonoids in Derris (Lonchocarpus urucu) by high-temperature high-resolution gas chromatography.

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12 December 2020

Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer

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12 December 2020

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

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12 December 2020

Natural products as leads to anticancer drugs

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12 December 2020

Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs

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12 December 2020

Polyamines as targets for therapeutic intervention

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12 December 2020

Advances in flavonoid research since 1992.

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12 December 2020

Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells.

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12 December 2020

Flavonoids: antioxidants or signalling molecules?

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12 December 2020

Flavonoids from Lonchocarpus latifolius roots

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12 December 2020

Molecular targets of breast cancer: AKTing in concert

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12 December 2020

Peroxisome proliferator activated receptor-γ (PPAR-γ) mediates the action of gamma linolenic acid in breast cancer cells

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12 December 2020

Reactive oxygen species in tumorigenesis.

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12 December 2020

In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain.

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12 December 2020

Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships

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12 December 2020

Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).

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12 December 2020

Flavonoids and the inhibition of PKC and PI 3-kinase

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12 December 2020

Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

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12 December 2020

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase

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12 December 2020

Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids

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12 December 2020

Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities

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12 December 2020

Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

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12 December 2020

Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells

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12 December 2020

Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells

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12 December 2020

Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells

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12 December 2020

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

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12 December 2020

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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12 December 2020

Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans

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12 December 2020

Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding

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12 December 2020

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.

1 reference

12 December 2020

Flavonoids from the stem bark of Lonchocarpus xuul

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12 December 2020

Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities

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12 December 2020

Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).

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12 December 2020

Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.

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12 December 2020

Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells

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12 December 2020

Molecular targeted therapies for breast cancer treatment

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12 December 2020

Flavonoids from Lonchocarpus muehlbergianus

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12 December 2020

Three-dimensional model of the human aromatase enzyme and density functional parameterization of the iron-containing protoporphyrin IX for a molecular dynamics study of heme-cysteinato cytochromes.

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12 December 2020

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

12 December 2020

Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol. from hops

1 reference

12 December 2020

Additional flavonoids from Lonchocarpus yucatanensis and L. xuul

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1590/S0103-50532005000600028

Identifiers

DOI

10.1007/S00894-009-0547-5

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17 December 2017

Dimensions Publication ID

1017898004

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17 December 2017