The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. (Q45937702)

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English	The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression.	scientific article

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2 February 2020

The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression (English)

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2 February 2020

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chronic lymphocytic leukemia

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Sophie Tartare-Deckert

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A D Baudot

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P Y Jeandel

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U Maurer

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S D Raynaud

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J P Cassuto

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M Ticchioni

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M Deckert

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6 July 2009

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3261-3273

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https://scigraph.springernature.com/pub.10.1038/onc.2009.179

0 references

Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

ZAP-70 Expression in Normal Pro/Pre B Cells, Mature B Cells, and in B-Cell Acute Lymphoblastic Leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Immunobiology of chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Proximal protein tyrosine kinases in immunoreceptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Syk-dependent mTOR activation in follicular lymphoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

ITAM-mediated tonic signalling through pre-BCR and BCR complexes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Regulation of B-cell fate by antigen-receptor signals

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Protein kinase Cdelta and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Distinctive activation mechanisms and functions for protein kinase Cdelta

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Chronic lymphocytic leukemia: revelations from the B-cell receptor.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Targeting Syk as a treatment for allergic and autoimmune disorders

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

21 January 2018

B-cell chronic lymphocytic leukemia: a bird of a different feather

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

31 March 2020

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

31 March 2020

Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.179

31 March 2020

Identifiers

10.1038/ONC.2009.179

1 reference

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2 February 2020

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