The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes. (Q46085427)

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23 January 2020

title

The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes (English)

1 reference

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23 January 2020

1 reference

1 reference

Nicholas A. Williamson

3

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23 January 2020

Eric C. Reynolds

5

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23 January 2020

Neil M O'Brien-Simpson

6

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23 January 2020

Anthony W. Purcell

7

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23 January 2020

Swee Heng Milon Pang

2

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23 January 2020

author name string

S I Mannering

1

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23 January 2020

G Naselli

4

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23 January 2020

L C Harrison

8

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23 January 2020

publication date

9 March 2009

1 reference

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Clinical and Experimental Immunology

23 January 2020

published in

1 reference

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23 January 2020

volume

156

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23 January 2020

issue

2

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23 January 2020

page(s)

226-231

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Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes

23 January 2020

cites work

1 reference

Crossref

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Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes

21 January 2018

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T-cell reactivity to insulin peptide A1-12 in children with recently diagnosed type 1 diabetes or multiple beta-cell autoantibodies

21 January 2018

1 reference

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Insulin as an autoantigen in NOD/human diabetes

3 November 2018

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DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype

3 November 2018

1 reference

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The insulin A-chain epitope recognized by human T cells is posttranslationally modified

3 November 2018

1 reference

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

3 November 2018

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An efficient method for cloning human autoantigen-specific T cells.

3 November 2018

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IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis

3 November 2018

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A sensitive method for detecting proliferation of rare autoantigen-specific human T cells

3 November 2018

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Proinsulin-a pathogenic autoantigen in type 1 diabetes.

3 November 2018

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Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice

3 November 2018

1 reference

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A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

3 November 2018

1 reference

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Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain.

3 November 2018

1 reference

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The role of assembly in insulin's biosynthesis

3 November 2018

1 reference

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T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

3 November 2018

1 reference

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Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759469

Expression, purification and characterization of recombinant human proinsulin

3 November 2018

1 reference

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Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. The Childhood Diabetes in Finland Study Group.

3 November 2018

1 reference

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Excessive secretion of insulin precursors characterizes and predicts gestational diabetes.

3 November 2018

1 reference

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Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family.

3 November 2018

1 reference

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Recent insights into CD4+T-cell specificity and function in Type 1 diabetes

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759469

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19292763

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1365-2249.2009.03907.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19292763%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

0 references

1 reference