Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase. (Q46087369)

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scientific article published in June 2009

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English	Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.	scientific article published in June 2009

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23 January 2020

Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase (English)

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23 January 2020

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23 January 2020

Giampaolo Manao

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Rosanna Maccari

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Rosanna Maccari

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Rosaria Ottanà

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Rosaria Ottanà

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23 January 2020

Rosella Ciurleo

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Rosella Ciurleo

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23 January 2020

Christian Laggner

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Christian Laggner

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23 January 2020

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1 June 2009

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23 January 2020

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23 January 2020

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23 January 2020

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

1 reference

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Modulation of protein kinase signaling by protein phosphatases and inhibitors

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Protein tyrosine phosphatases in the human genome

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Protein tyrosine phosphatases and signalling

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Protein tyrosine phosphatase function: the substrate perspective

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Protein tyrosine phosphatases: structure-function relationships

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Protein tyrosine phosphatases: prospects for therapeutics

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Selecting protein tyrosine phosphatases as drug targets

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Inhibitors of protein tyrosine phosphatases: next-generation drugs?

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Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.

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Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

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7 January 2021

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Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

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LMW-PTP is a negative regulator of insulin-mediated mitotic and metabolic signalling

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7 January 2021

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LMW-PTP exerts a differential regulation on PDGF- and insulin-mediated signaling

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7 January 2021

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Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice

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7 January 2021

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Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes

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7 January 2021

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The metabolic syndrome

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7 January 2021

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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7 January 2021

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Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

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7 January 2021

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Protein tyrosine phosphatase 1B inhibitors for diabetes

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7 January 2021

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Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus

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7 January 2021

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PTP1B as a drug target: recent developments in PTP1B inhibitor discovery

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7 January 2021

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LMW-PTP is a positive regulator of tumor onset and growth

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Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers

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Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

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7 January 2021

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Targeting PTPs with small molecule inhibitors in cancer treatment

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The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B

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Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

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The molecular basis of the differing kinetic behavior of the two low molecular mass phosphotyrosine protein phosphatase isoforms

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Crystal structure of the human B-form low molecular weight phosphotyrosyl phosphatase at 1.6-A resolution

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1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors

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Identifiers

10.1002/CMDC.200800427

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19288492%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19288492%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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