Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug (Q46362610)

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English	Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug	scientific article

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scholarly article

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28530702

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug (English)

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28530702

type 2 diabetes

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Marcus Ståhlman

7

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21 December 2017

http://europepmc.org/abstract/MED/28530702

13

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http://europepmc.org/abstract/MED/28530702

Mercè Planas-Fèlix

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Mercè Planas-Fèlix

10

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Valentina Tremaroli

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Valentina Tremaroli

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Josep Maria Mercader

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Josep M Mercader

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Matteo Serino

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Fredrik Bäckhed

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Fredrik Bäckhed

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Louise Mannerås-Holm

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Louise Mannerås-Holm

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http://europepmc.org/abstract/MED/28530702

5

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Robert Caesar

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Rémy Burcelin

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Muhammad Tanweer Khan

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Muhammad Tanweer Khan

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Hao Wu

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Eduardo Esteve

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http://europepmc.org/abstract/MED/28530702

Lisa M Olsson

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Gemma Xifra

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http://europepmc.org/abstract/MED/28530702

Wifredo Ricart

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Rosie Perkins

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José Manuel Fernàndez-Real

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22 May 2017

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Nature Medicine

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23

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http://europepmc.org/abstract/MED/28530702

850-858

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http://europepmc.org/abstract/MED/28530702

7

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https://scigraph.springernature.com/pub.10.1038/nm.4345

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Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

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Metformin--mode of action and clinical implications for diabetes and cancer

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Role of AMP-activated protein kinase in mechanism of metformin action

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

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7 January 2021

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

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Metformin and the gastrointestinal tract

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Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.

1 reference

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Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect

1 reference

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Randomized Clinical Trial Comparing Basal Insulin Peglispro and Insulin Glargine in Patients With Type 2 Diabetes Previously Treated With Basal Insulin: IMAGINE 5.

1 reference

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7 January 2021

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An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

1 reference

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7 January 2021

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Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

1 reference

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7 January 2021

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Effect of metformin on metabolic improvement and gut microbiota

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Gut metagenome in European women with normal, impaired and diabetic glucose control

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Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

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Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut.

1 reference

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7 January 2021

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Metagenomic data utilization and analysis (MEDUSA) and construction of a global gut microbial gene catalogue

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Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.

1 reference

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Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

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7 January 2021

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Blautia stercoris sp. nov., isolated from human faeces

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Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples

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KEGG: kyoto encyclopedia of genes and genomes

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Colonic health: fermentation and short chain fatty acids

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7 January 2021

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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

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Consequences of bile salt biotransformations by intestinal bacteria

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Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides

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7 January 2021

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Effect of metformin on bile salt circulation and intestinal motility in type 2 diabetes mellitus.

1 reference

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7 January 2021

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Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

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7 January 2021

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Dietary intervention impact on gut microbial gene richness

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Bifidobacterium adolescentis supplementation ameliorates visceral fat accumulation and insulin sensitivity in an experimental model of the metabolic syndrome

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A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

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Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome

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A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice.

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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

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Host adaptive immunity alters gut microbiota

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Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly.

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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation.

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The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies.

1 reference

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12 December 2020

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10.1038/NM.4345

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28530702

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28530702

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