Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability. (Q46407039)

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13 January 2020

title

Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability (English)

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3

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author name string

Sayuko Kaminosono

1

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13 January 2020

Taro Saito

2

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13 January 2020

Toshio Ohshima

4

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13 January 2020

Akiko Asada

5

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13 January 2020

Yoshitaka Nagai

6

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13 January 2020

Nobuyuki Nukina

7

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13 January 2020

Shin-Ichi Hisanaga

8

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language of work or name

English

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publication date

1 August 2008

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13 January 2020

published in

Journal of Neuroscience

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13 January 2020

volume

28

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issue

35

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13 January 2020

page(s)

8747-8755

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Rapid aggregate formation of the huntingtin N-terminal fragment carrying an expanded polyglutamine tract

13 January 2020

cites work

1 reference

12 December 2020

Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells

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12 December 2020

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

1 reference

12 December 2020

Huntington's disease: the challenge for cell biologists

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12 December 2020

NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein

1 reference

12 December 2020

Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy

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12 December 2020

1 reference

12 December 2020

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

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12 December 2020

Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

1 reference

12 December 2020

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

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12 December 2020

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

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12 December 2020

Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation

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12 December 2020

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

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12 December 2020

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

1 reference

12 December 2020

Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization

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12 December 2020

The hunt for huntingtin function: interaction partners tell many different stories

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12 December 2020

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator

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12 December 2020

Cyclin-dependent kinase-5 in neurodegeneration.

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12 December 2020

Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi

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12 December 2020

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

1 reference

12 December 2020

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

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12 December 2020

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

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12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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12 December 2020

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

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12 December 2020

Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39

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12 December 2020

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

1 reference

12 December 2020

Normal huntingtin function: an alternative approach to Huntington's disease

1 reference

12 December 2020

Modulation of Reelin signaling by Cyclin-dependent kinase 5.

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12 December 2020

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

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12 December 2020

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

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12 December 2020

A toxic monomeric conformer of the polyglutamine protein

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12 December 2020

Microtubule association of the neuronal p35 activator of Cdk5.

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12 December 2020

The roles of cyclin-dependent kinase 5 in dendrite and synapse development

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12 December 2020

Huntingtin facilitates dynein/dynactin-mediated vesicle transport.

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12 December 2020

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

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12 December 2020

Global changes to the ubiquitin system in Huntington's disease.

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12 December 2020

Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.

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12 December 2020

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

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12 December 2020

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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12 December 2020

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

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12 December 2020

Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells

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12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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12 December 2020

Microtubule-stimulated phosphorylation of tau at Ser202 and Thr205 by cdk5 decreases its microtubule nucleation activity.

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12 December 2020

Aggresomes: a cellular response to misfolded proteins

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12 December 2020

10.1523/JNEUROSCI.0973-08.2008

Identifiers

DOI

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