CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment (Q46457840)

22 December 2017

title

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment (English)

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22 December 2017

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Hélène Bour-Jordan

1

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22 December 2017

Jane L Grogan

2

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22 December 2017

Qizhi Tang

3

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22 December 2017

Julie A Auger

4

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22 December 2017

Richard M Locksley

5

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22 December 2017

Jeffrey A Bluestone

6

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22 December 2017

language of work or name

English

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publication date

13 January 2003

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22 December 2017

published in

Nature Immunology

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22 December 2017

volume

4

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22 December 2017

issue

2

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22 December 2017

page(s)

182-188

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22 December 2017

An interleukin-4-induced transcription factor: IL-4 Stat

cites work

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Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

21 January 2018

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

21 January 2018

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Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

21 January 2018

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

21 January 2018

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Essential role of Stat6 in IL-4 signalling

21 January 2018

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The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

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Functional responses and costimulator dependence of memory CD4+ T cells.

21 January 2018

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Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

21 January 2018

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The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

21 January 2018

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Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

21 January 2018

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Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter

21 January 2018

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The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

21 January 2018

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Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

21 January 2018

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NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

21 January 2018

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IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

21 January 2018

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Role of IRS-2 in insulin and cytokine signalling

21 January 2018

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STAT6, NF-kappaB and C/EBP in CD23 expression and IgE production

21 January 2018

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Inhibition of IgG1 and IgE production by stimulation of the B cell CTLA-4 receptor

21 January 2018

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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

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T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.

21 January 2018

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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

21 January 2018

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Stat6 regulation of in vivo IL-4 responses

21 January 2018

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Molecular basis of T cell inactivation by CTLA-4

21 January 2018

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Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription

21 January 2018

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The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells

21 January 2018

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The Src family kinase Fyn mediates signals induced by TCR antagonists

21 January 2018

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Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

21 January 2018

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CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells

21 January 2018

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CTLA-4 engagement regulates NF-kappaB activation in vivo

21 January 2018

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CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

21 January 2018

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7 January 2021

Polarization of naive CD4+ T cells toward the Th1 subset by CTLA-4 costimulation

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7 January 2021

Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

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7 January 2021

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

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7 January 2021

CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts

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7 January 2021

Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

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7 January 2021

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

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7 January 2021

Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo

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7 January 2021

Identifiers

DOI

10.1038/NI884

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22 December 2017

release_v67qupd7ajghbn6yt27zl5xk2i

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/v67qupd7ajghbn6yt27zl5xk2i

24 November 2022

mapped directly with Wikidata item

PubMed ID

12524538

1 reference

22 December 2017