A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites (Q46633348)

23 December 2017

title

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites (English)

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23 December 2017

Marcel Tijsterman

6

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author name string

Wouter Koole

1

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23 December 2017

Robin van Schendel

2

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23 December 2017

Andrea E Karambelas

3

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23 December 2017

Jane T van Heteren

4

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23 December 2017

Kristy L Okihara

5

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23 December 2017

language of work or name

English

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publication date

1 January 2014

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23 December 2017

published in

Nature Communications

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23 December 2017

volume

5

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23 December 2017

page(s)

3216

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23 December 2017

https://scigraph.springernature.com/pub.10.1038/ncomms4216

exact match

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cites work

Helix formation by guanylic acid

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Epigenetic instability due to defective replication of structured DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Prevalence of quadruplexes in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

DNA secondary structures and epigenetic determinants of cancer genome evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

High-efficiency bypass of DNA damage by human DNA polymerase Q

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Promiscuous DNA synthesis by human DNA polymerase θ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

The million mutation project: a new approach to genetics in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Transcription of a cis-acting, noncoding, small RNA is required for pilin antigenic variation in Neisseria gonorrhoeae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Identification of genes expressed in the hermaphrodite germ line of C. elegans using SAGE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Overexpression of POLQ confers a poor prognosis in early breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Single-copy insertion of transgenes in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

7 January 2021

Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

7 January 2021

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

7 January 2021

Targeted alterations of the Caenorhabditis elegans genome by transgene instructed DNA double strand break repair following Tc1 excision

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

7 January 2021

Intrinsic coupling of lagging-strand synthesis to chromatin assembly.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

7 January 2021

Isolation of deletion alleles by G4 DNA-induced mutagenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

7 January 2021

Characterization of mutations induced by ethyl methanesulfonate, UV, and trimethylpsoralen in the nematode Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4216

7 January 2021

Identifiers

DOI

10.1038/NCOMMS4216

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23 December 2017

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23 December 2017