BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance. (Q46807683)

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English	BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.	scientific article

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scholarly article

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9 January 2020

BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16291747%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Fionnuala B Hickey

1

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9 January 2020

Thomas G Cotter

2

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9 January 2020

author name string

Fionnuala B Hickey

1

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/16291747

Thomas G Cotter

2

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/16291747

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publication date

16 November 2005

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9 January 2020

Journal of Biological Chemistry

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9 January 2020

281

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9 January 2020

2441-2450

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9 January 2020

5

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9 January 2020

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1 reference

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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

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Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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Phosphatidylinositol 3-kinase

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21 January 2018

Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells

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Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants

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Phosphoinositide kinases

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

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Signalling through the lipid products of phosphoinositide-3-OH kinase

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Differential sensitivity of phosphatidylinositol 3-kinase p110gamma to isoforms of G protein betagamma dimers

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21 January 2018

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

1 reference

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21 January 2018

Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

1 reference

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Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

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The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase

1 reference

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Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells

1 reference

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21 January 2018

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

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MEK kinase 1 mediates the antiapoptotic effect of the Bcr-Abl oncogene through NF-κB activation

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Phosphorylation of c-Raf-1 by protein kinase A interferes with activation

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Protein kinase C activity is necessary for estrogen-induced Erk phosphorylation in neocortical explants

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21 January 2018

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

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21 January 2018

Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase.

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21 January 2018

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties

1 reference

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21 January 2018

Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits

1 reference

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21 January 2018

Activation of phosphoinositide 3-kinase gamma by Ras.

1 reference

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21 January 2018

A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.

1 reference

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21 January 2018

An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.

1 reference

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21 January 2018

Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors

1 reference

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21 January 2018

Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration

1 reference

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21 January 2018

PI3K-Akt pathway: its functions and alterations in human cancer

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The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

1 reference

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Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis

1 reference

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Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

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Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

1 reference

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A role for increased mRNA stability in the induction of endothelin-1 synthesis by lipopolysaccharide.

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The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

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Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

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Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

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Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo

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Identifiers

10.1074/JBC.M511173200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16291747%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16291747%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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