Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. (Q46886447)

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27 December 2019

title

Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis (English)

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27 December 2019

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9

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27 December 2019

author name string

Diana Steckley

1

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27 December 2019

Meera Karajgikar

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27 December 2019

Lianne B Dale

3

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27 December 2019

Ben Fuerth

4

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27 December 2019

Patrick Swan

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27 December 2019

Chris Drummond-Main

6

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27 December 2019

Michael O Poulter

7

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27 December 2019

Stephen S G Ferguson

8

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27 December 2019

Sean P Cregan

10

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27 December 2019

language of work or name

English

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publication date

1 November 2007

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27 December 2019

published in

Journal of Neuroscience

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27 December 2019

volume

27

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27 December 2019

issue

47

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27 December 2019

page(s)

12989-12999

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Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.

27 December 2019

cites work

1 reference

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Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

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Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage.

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Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons.

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

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Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

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12 December 2020

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

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12 December 2020

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons

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12 December 2020

Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury

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APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

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BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

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Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins.

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

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Cell death regulation by the Bcl-2 protein family in the mitochondria

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12 December 2020

Targeting programmed cell death in neurodegenerative diseases

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12 December 2020

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

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12 December 2020

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

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12 December 2020

Nitric oxide and reactive oxygen species in Parkinson's disease

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12 December 2020

Caspase activation in the limbic cortex of subjects with early Alzheimer's disease.

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12 December 2020

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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12 December 2020

Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis.

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12 December 2020

Reactive Oxygen Radicals and Pathogenesis of Neuronal Death After Cerebral Ischemia

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12 December 2020

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

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12 December 2020

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

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12 December 2020

Role of AIF in caspase-dependent and caspase-independent cell death

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12 December 2020

Oxidative stress in neurodegeneration: cause or consequence?

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12 December 2020

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

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12 December 2020

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

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12 December 2020

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death

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12 December 2020

Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia

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12 December 2020

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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12 December 2020

Noxa is a critical mediator of p53-dependent motor neuron death after nerve injury in adult mouse

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12 December 2020

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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12 December 2020

Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease

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12 December 2020

Reactive oxygen and nitrogen species in Alzheimer's disease

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12 December 2020

Antioxidant strategies in the treatment of stroke

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12 December 2020

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

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12 December 2020

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons

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12 December 2020

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

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12 December 2020

Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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12 December 2020

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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12 December 2020

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

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12 December 2020

The role of free radicals and p53 in neuron apoptosis in vivo.

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12 December 2020

Evidence for p53-mediated modulation of neuronal viability.

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12 December 2020

Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons.

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12 December 2020

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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12 December 2020

MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.

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12 December 2020

Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

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12 December 2020

Movement of Bax from the cytosol to mitochondria during apoptosis

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12 December 2020

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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12 December 2020

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

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12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

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12 December 2020

Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies.

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12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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12 December 2020

Blocking cytochrome c activity within intact neurons inhibits apoptosis.

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12 December 2020

A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

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12 December 2020

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

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12 December 2020

Regulated targeting of BAX to mitochondria.

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12 December 2020

Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c

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12 December 2020

10.1523/JNEUROSCI.3400-07.2007

Identifiers

DOI

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27 December 2019

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27 December 2019

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