The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. (Q53234112)

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scientific article published in June 2000

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English	The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.	scientific article published in June 2000

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scholarly article

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. (English)

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

2

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Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

author name string

Saura CA

1

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Soriano S

3

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Takahashi M

4

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Leem JY

5

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Honda T

6

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Koo EH

7

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Iwatsubo T

8

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Thinakaran G

9

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Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

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publication date

1 June 2000

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Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Journal of Biological Chemistry

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Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

275

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http://europepmc.org/abstract/MED/10748144

17136-17142

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http://europepmc.org/abstract/MED/10748144

22

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Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

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21 January 2018

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

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21 January 2018

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

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21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

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21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

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21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Function and dysfunction of the presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Presenilins are processed by caspase-type proteases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

The role of presenilins in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Dual roles of proteasome in the metabolism of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Lack of requirement for presenilin1 in Notch1 signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M909624199

21 January 2018

Identifiers

10.1074/JBC.M909624199

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

1 reference

Europe PubMed Central

12 May 2018

http://europepmc.org/abstract/MED/10748144

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