Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain. (Q48875498)

16 February 2018

title

Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain. (English)

1 reference

16 February 2018

main subject

metastatic breast cancer

1 reference

19

Patricia S Steeg

1 reference

16 February 2018

author name string

Yongzhen Qian

1

1 reference

16 February 2018

Emily Hua

2

1 reference

16 February 2018

Kheem Bisht

3

1 reference

16 February 2018

Stephan Woditschka

4

1 reference

16 February 2018

Konstantine W Skordos

5

1 reference

16 February 2018

David J Liewehr

6

1 reference

16 February 2018

Seth M Steinberg

7

1 reference

16 February 2018

Edi Brogi

8

1 reference

16 February 2018

Muzaffar M Akram

9

1 reference

16 February 2018

J Keith Killian

10

1 reference

16 February 2018

Daniel C Edelman

11

1 reference

16 February 2018

Marbin Pineda

12

1 reference

16 February 2018

Stephanie Scurci

13

1 reference

16 February 2018

Yan Y Degenhardt

14

1 reference

16 February 2018

Sylvie Laquerre

15

1 reference

16 February 2018

Thomas A Lampkin

16

1 reference

16 February 2018

Paul S Meltzer

17

1 reference

16 February 2018

Kevin Camphausen

18

1 reference

16 February 2018

Diane Palmieri

20

1 reference

16 February 2018

publication date

21 September 2011

1 reference

16 February 2018

Clinical & Experimental Metastasis

published in

1 reference

16 February 2018

volume

28

1 reference

16 February 2018

page(s)

899-908

1 reference

16 February 2018

issue

8

1 reference

16 February 2018

https://scigraph.springernature.com/pub.10.1007/s10585-011-9421-9

exact match

0 references

cites work

Breast cancer metastasis to the central nervous system

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Brain metastases as preventive and therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Mitotic drug targets and the development of novel anti-mitotic anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Targeting Polo-like kinase in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

High incidence of central nervous system involvement in patients with metastatic or locally advanced breast cancer treated with epirubicin and docetaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Response of brain metastases from breast cancer to systemic chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Polo-like kinases and the orchestration of cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Polo-like kinase 1 is involved in invasion through extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

TP53 status and response to chemotherapy in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Accumulation of genetic alterations in brain metastases of sporadic breast carcinomas is associated with reduced survival after metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Latent bone metastasis in breast cancer tied to Src-dependent survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

The blood-brain barrier and cancer: transporters, treatment, and Trojan horses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Tumor metastasis: mechanistic insights and clinical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Plk1-mediated phosphorylation of Topors regulates p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Polo-like kinase 1 as predictive marker and therapeutic target for radiotherapy in rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-011-9421-9

Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease

21 January 2018

1 reference

12 December 2020

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

1 reference

12 December 2020

Central nervous system progression of metastatic breast cancer in patients treated with paclitaxel

1 reference

12 December 2020

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

1 reference

12 December 2020

Loss of heterozygosity accumulation in primary breast carcinomas and additionally in corresponding distant metastases is associated with poor outcome

1 reference

12 December 2020

Polo-like kinase: a novel marker of proliferation: correlation with estrogen-receptor expression in human breast cancer

1 reference

12 December 2020

Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function

1 reference

12 December 2020

10.1007/S10585-011-9421-9

Identifiers

DOI

1 reference

16 February 2018

0 references

1 reference

16 February 2018