5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. (Q49344600)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Kasper Skytte Harpsøe

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Shuguang Yuan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Louise F Nikolajsen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

Walden E. Bjørn-Yoshimoto

14 March 2020

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Vsevolod Katritch

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

David E. Gloriam

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Raymond C. Stevens

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

2

John D McCorvy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

24

Bryan L Roth

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

21

Michael A Hanson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

17

Gye Won Han

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

26

Zhi-Jie Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

author name string

Yao Peng

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Katherine Lansu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Petr Popov

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Mengchen Pu

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Tao Che

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Xi-Ping Huang

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Yiran Wu

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Ling Shen

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Kang Ding

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Daniel Wacker

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Jianjun Cheng

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Suwen Zhao

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Lu Qu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

language of work or name

English

0 references

publication date

1 February 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

volume

172

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

page(s)

719-730.e14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands

14 March 2020

cites work

1 reference

12 December 2020

Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

1 reference

12 December 2020

Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

1 reference

12 December 2020

Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

1 reference

12 December 2020

Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719

1 reference

12 December 2020

Ritanserin as add-on medication to neuroleptic therapy for patients with chronic or subchronic schizophrenia.

1 reference

12 December 2020

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

1 reference

12 December 2020

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

1 reference

12 December 2020

The CCP4 suite: programs for protein crystallography

1 reference

12 December 2020

Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system

1 reference

12 December 2020

Drugs and valvular heart disease

1 reference

12 December 2020

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

12 December 2020

The genetic design of signaling cascades to record receptor activation

1 reference

12 December 2020

Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization

1 reference

12 December 2020

Microscale fluorescent thermal stability assay for membrane proteins

1 reference

12 December 2020

Crystallizing membrane proteins using lipidic mesophases

1 reference

12 December 2020

Phasercrystallographic software

1 reference

12 December 2020

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.

1 reference

12 December 2020

Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment

1 reference

12 December 2020

1 reference

12 December 2020

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

12 December 2020

Features and development of Coot

1 reference

12 December 2020

Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

1 reference

12 December 2020

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

1 reference

12 December 2020

A ligand's view of target similarity: chemogenomic binding site-directed techniques for drug discovery

1 reference

12 December 2020

Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

1 reference

12 December 2020

Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo

1 reference

12 December 2020

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

12 December 2020

Structure and dynamics of the M3 muscarinic acetylcholine receptor

1 reference

12 December 2020

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

1 reference

12 December 2020

Automated design of ligands to polypharmacological profiles.

1 reference

12 December 2020

Molecular signatures of G-protein-coupled receptors

1 reference

12 December 2020

Structural Basis for Molecular Recognition at Serotonin Receptors

1 reference

12 December 2020

Structural Features for Functional Selectivity at Serotonin Receptors

1 reference

12 December 2020

Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective

1 reference

12 December 2020

The ChEMBL bioactivity database: an update

1 reference

12 December 2020

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs

1 reference

12 December 2020

Serial Femtosecond Crystallography of G Protein-Coupled Receptors

1 reference

12 December 2020

Computational studies to predict or explain G protein coupled receptor polypharmacology

1 reference

12 December 2020

Structure and function of serotonin G protein-coupled receptors.

1 reference

12 December 2020

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

1 reference

12 December 2020

Comprehensive characterization of the Published Kinase Inhibitor Set

1 reference

12 December 2020

GPCRdb: an information system for G protein-coupled receptors.

1 reference

12 December 2020

1 reference

12 December 2020

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

1 reference

12 December 2020

Structure-based discovery of opioid analgesics with reduced side effects

1 reference

12 December 2020

Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists

1 reference

12 December 2020

Computational polypharmacology: a new paradigm for drug discovery

1 reference

12 December 2020

Crystal Structure of an LSD-Bound Human Serotonin Receptor

1 reference

12 December 2020

A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment

1 reference

12 December 2020

5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice.

1 reference

12 December 2020

Aripiprazole, a Drug that Displays Partial Agonism and Functional Selectivity

1 reference

12 December 2020

An Expanded View of Complex Traits: From Polygenic to Omnigenic

1 reference

12 December 2020

How Ligands Illuminate GPCR Molecular Pharmacology

1 reference

12 December 2020

D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.

1 reference

12 December 2020

10.1016/J.CELL.2018.01.001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29398112%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

29398112

1 reference