Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. (Q50665953)

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7 January 2020

title

Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood (English)

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7 January 2020

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4

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author name string

J Perry Hall

1

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7 January 2020

Yahya Kurdi

2

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7 January 2020

Sang Hsu

3

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Julie Liu

5

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7 January 2020

Jean-Baptiste Telliez

6

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Katherine J Seidl

7

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Aaron Winkler

8

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Yonghan Hu

9

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Neal Green

10

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G Roger Askew

11

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Steve Tam

12

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James D Clark

13

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Lih-Ling Lin

14

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language of work or name

English

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publication date

11 September 2007

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Journal of Biological Chemistry

7 January 2020

published in

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volume

282

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7 January 2020

issue

46

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7 January 2020

page(s)

33295-33304

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Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

7 January 2020

cites work

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

21 January 2018

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Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

21 January 2018

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Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

21 January 2018

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

21 January 2018

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TRAF6 and Src kinase activity regulates Cot activation by IL-1.

21 January 2018

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Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.

21 January 2018

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Cytokine pathways and joint inflammation in rheumatoid arthritis

21 January 2018

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Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

21 January 2018

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Biology of tumor necrosis factor-alpha- implications for psoriasis

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What makes a good anti-inflammatory drug target?

21 January 2018

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Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period

21 January 2018

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Comparative analysis of various in vitro COT kinase assay formats and their applications in inhibitor identification and characterization

21 January 2018

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Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase

21 January 2018

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Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships

21 January 2018

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Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

21 January 2018

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Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.

21 January 2018

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Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling

21 January 2018

1 reference

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15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.

21 January 2018

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Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

21 January 2018

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Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity

21 January 2018

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Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?

21 January 2018

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Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes

21 January 2018

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Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

21 January 2018

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Cytokines, metalloproteinases, their inhibitors and cartilage oligomeric matrix protein: relationship to radiological progression and inflammation in early rheumatoid arthritis. A prospective 5-year study.

21 January 2018

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Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

21 January 2018

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ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M703694200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848581%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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