Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. (Q50948674)

25 March 2018

title

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. (English)

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4

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author name string

Tokio Matsuzaki

1

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Takehiko Matsushita

2

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Koji Takayama

3

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Kotaro Nishida

5

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Ryosuke Kuroda

6

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Masahiro Kurosaka

7

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language of work or name

English

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publication date

30 May 2013

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25 March 2018

Annals of the Rheumatic Diseases

published in

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volume

73

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issue

7

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page(s)

1397-1404

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25 March 2018

Osteoarthritis: pathobiology-targets and ways for therapeutic intervention

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

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Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase.

21 January 2018

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Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase

21 January 2018

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21 January 2018

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SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway.

21 January 2018

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SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes.

21 January 2018

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21 January 2018

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Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

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Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation

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Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

21 January 2018

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SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice.

21 January 2018

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Osteoarthritis cartilage histopathology: grading and staging.

21 January 2018

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

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Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response

21 January 2018

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Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

21 January 2018

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75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

21 January 2018

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Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

21 January 2018

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TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc

21 January 2018

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Progressive loss of SIRT1 with cell cycle withdrawal

21 January 2018

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SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons

21 January 2018

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Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction.

21 January 2018

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The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation

21 January 2018

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10.1136/ANNRHEUMDIS-2012-202620

21 January 2018

Identifiers

DOI

1 reference

25 March 2018

PubMed ID

23723318

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25 March 2018