Autocrine insulin action activates Akt and increases survival of isolated human islets. (Q51115965)

30 March 2018

title

Autocrine insulin action activates Akt and increases survival of isolated human islets. (English)

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30 March 2018

3

D Maysinger

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30 March 2018

Lawrence Rosenberg

7

object named as

L Rosenberg

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30 March 2018

author name string

R Aikin

1

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30 March 2018

S Hanley

2

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M Lipsett

4

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M Castellarin

5

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S Paraskevas

6

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publication date

20 October 2006

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30 March 2018

published in

Diabetologia

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30 March 2018

volume

49

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30 March 2018

issue

12

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page(s)

2900-2909

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30 March 2018

https://scigraph.springernature.com/pub.10.1007/s00125-006-0476-0

exact match

0 references

cites work

Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00125-006-0476-0

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

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12 December 2020

Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets

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12 December 2020

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

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12 December 2020

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice

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12 December 2020

Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets

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12 December 2020

Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death.

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12 December 2020

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

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12 December 2020

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

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12 December 2020

Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells

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12 December 2020

Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro

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12 December 2020

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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12 December 2020

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

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12 December 2020

Structural biology of insulin and IGF1 receptors: implications for drug design

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12 December 2020

Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells

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12 December 2020

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

12 December 2020

Cellular survival: a play in three Akts

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12 December 2020

Cell loss in isolated human islets occurs by apoptosis

1 reference

12 December 2020

Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay

1 reference

12 December 2020

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

1 reference

12 December 2020

Cellular signaling: pivoting around PDK-1.

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12 December 2020

Insulin structure and stability.

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12 December 2020

Revascularization and microcirculation of freely grafted islets of Langerhans

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12 December 2020

Automated method for isolation of human pancreatic islets

1 reference

12 December 2020

Phosphatidylinositol 3-kinase signaling to Akt mediates survival in isolated canine islets of Langerhans

1 reference

12 December 2020

Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins

1 reference

12 December 2020

Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival

1 reference

12 December 2020

PI 3-kinase, Akt and cell survival

1 reference

12 December 2020

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin

1 reference

12 December 2020

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

1 reference

12 December 2020

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways

1 reference

12 December 2020

Effects of Glucose and 3′,5′-Cyclic Adenosine Monophosphate upon Reaggregation of Single Pancreatic B-Cells*

1 reference

12 December 2020

Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes

1 reference

12 December 2020

Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes

1 reference

12 December 2020

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

1 reference

12 December 2020

Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal

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12 December 2020

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

1 reference

12 December 2020

Autocrine regulation of single pancreatic beta-cell survival

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12 December 2020

Pretransplant culture selects for high-quality porcine islets

1 reference

12 December 2020

Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets

1 reference

12 December 2020

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells

1 reference

12 December 2020

Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death

1 reference

12 December 2020

Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience

1 reference

12 December 2020

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

12 December 2020

Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

1 reference

12 December 2020

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

12 December 2020

Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics

1 reference

12 December 2020

Inhibition of caspase-mediated PARP-1 cleavage results in increased necrosis in isolated islets of Langerhans

1 reference

12 December 2020

Pharmacological agents that directly modulate insulin secretion

1 reference

12 December 2020

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

1 reference

12 December 2020

10.1007/S00125-006-0476-0

Identifiers

DOI

1 reference

30 March 2018

PubMed ID

17053882

1 reference

30 March 2018