Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. (Q51673706)

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scientific article published on 29 June 2016

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English	Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.	scientific article published on 29 June 2016

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scholarly article

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. (English)

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

author name string

María Ordóñez-Robles

1

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

Antonio Rodríguez-García

2

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

Juan F Martín

3

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

language of work or name

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publication date

29 June 2016

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Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

Applied Microbiology and Biotechnology

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Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

100

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Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

18

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Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

8091-8103

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

https://scigraph.springernature.com/pub.10.1007/s00253-016-7696-0

0 references

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

1 reference

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Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).

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Annotation of the modular polyketide synthase and nonribosomal peptide synthetase gene clusters in the genome of Streptomyces tsukubaensis NRRL18488.

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A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877.

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Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems

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Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum

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FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

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A new enzyme superfamily - the phosphopantetheinyl transferases

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Molecular regulation of antibiotic biosynthesis in streptomyces.

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Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

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The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation

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Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'.

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Tacrolimus: in heart transplant recipients

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Immunosuppression: evolution in practice and trends, 1994-2004.

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Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

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21 January 2018

Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP

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Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.

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Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520

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The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms

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Identifiers

10.1007/S00253-016-7696-0

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

1 reference

Europe PubMed Central

9 April 2018

http://europepmc.org/abstract/MED/27357227

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