Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. (Q52375459)

30 April 2018

http://europepmc.org/abstract/MED/29466332

title

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. (English)

1 reference

30 April 2018

http://europepmc.org/abstract/MED/29466332

main subject

cryogenic electron microscopy

0 references

author

Alisa Glukhova

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29466332%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Sebastian Furness

4

1 reference

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4 June 2020

David M Thal

9

1 reference

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4 June 2020

Arthur Christopoulos

16

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4 June 2020

Patrick M. Sexton

17

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4 June 2020

15

Laurence J Miller

1 reference

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4 June 2020

7

Cassandra Koole

1 reference

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4 June 2020

18

Denise Wootten

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4 June 2020

1

Yi-Lynn Liang

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4 June 2020

2

Maryam Khoshouei

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4 June 2020

5

Peishen Zhao

1 reference

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4 June 2020

6

Lachlan Clydesdale

1 reference

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4 June 2020

10

Saifei Lei

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4 June 2020

12

Radostin Danev

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4 June 2020

author name string

Tin T Truong

8

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4 June 2020

Mazdak Radjainia

11

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4 June 2020

Wolfgang Baumeister

13

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4 June 2020

Ming-Wei Wang

14

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4 June 2020

language of work or name

English

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publication date

21 February 2018

1 reference

30 April 2018

http://europepmc.org/abstract/MED/29466332

published in

Nature

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29466332%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

555

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4 June 2020

issue

7694

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4 June 2020

page(s)

121-125

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Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes

4 June 2020

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7 January 2021

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

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Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1.

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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

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7 January 2021

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.

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Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

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Peptide binding at the GLP-1 receptor.

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Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications.

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7 January 2021

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

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7 January 2021

Volta potential phase plate for in-focus phase contrast transmission electron microscopy.

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7 January 2021

Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate.

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7 January 2021

Volta phase plate cryo-EM of the small protein complex Prx3

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7 January 2021

Structure of the human glucagon class B G-protein-coupled receptor

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7 January 2021

Structure of class B GPCR corticotropin-releasing factor receptor 1

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7 January 2021

Crystal structure of the GLP-1 receptor bound to a peptide agonist.

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7 January 2021

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

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7 January 2021

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

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7 January 2021

Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor

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7 January 2021

The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling

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7 January 2021

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

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7 January 2021

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

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7 January 2021

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)

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7 January 2021

Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain

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7 January 2021

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

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7 January 2021

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

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7 January 2021

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

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7 January 2021

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

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7 January 2021

The N54 mutant of Galphas has a conditional dominant negative phenotype which suppresses hormone-stimulated but not basal cAMP levels

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7 January 2021

A Gsalpha mutant designed to inhibit receptor signaling through Gs.

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7 January 2021

A highly effective dominant negative alpha s construct containing mutations that affect distinct functions inhibits multiple Gs-coupled receptor signaling pathways

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7 January 2021

Identification of effector-activating residues of Gs alpha

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7 January 2021

Automated electron microscope tomography using robust prediction of specimen movements

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7 January 2021

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

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7 January 2021

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7 January 2021

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7 January 2021

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2.

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7 January 2021

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7 January 2021

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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7 January 2021

MolProbity: all-atom structure validation for macromolecular crystallography

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7 January 2021

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7 January 2021

β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues.

1 reference

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7 January 2021

UCSF Chimera--a visualization system for exploratory research and analysis

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7 January 2021

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29466332

12 December 2020

inferred from PubMed ID database lookup

The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29466332

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NATURE25773

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29466332%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference