The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease. (Q52757816)

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28 March 2020

title

The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease (English)

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28 March 2020

1

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28 March 2020

author name string

Toshifumi Sugatani

2

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28 March 2020

Olga A Agapova

3

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28 March 2020

Yifu Fang

4

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28 March 2020

Joseph P Gaut

5

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28 March 2020

Marie-Claude Faugere

6

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28 March 2020

Hartmut H Malluche

7

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28 March 2020

Keith A Hruska

8

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language of work or name

English

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publication date

23 August 2017

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28 March 2020

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28 March 2020

volume

93

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28 March 2020

page(s)

147-158

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28 March 2020

issue

1

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Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells

28 March 2020

cites work

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Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures

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Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors

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Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries

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Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin

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Activin signaling as an emerging target for therapeutic interventions

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Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease

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A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

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Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo

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Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective

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12 December 2020

Klotho deficiency causes vascular calcification in chronic kidney disease

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12 December 2020

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

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Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease

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Osteocyte RANKL: new insights into the control of bone remodeling

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Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy

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Early chronic kidney disease-mineral bone disorder stimulates vascular calcification

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Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

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Translational profiles of medullary myofibroblasts during kidney fibrosis.

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The kidney is the principal organ mediating klotho effects

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Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl

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Alport syndrome from bench to bedside: the potential of current treatment beyond RAAS blockade and the horizon of future therapies

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BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway

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Klotho and phosphate are modulators of pathologic uremic cardiac remodeling

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12 December 2020

Searching for a treatment for Alport syndrome using mouse models

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12 December 2020

Pathology vs. molecular genetics: (re)defining the spectrum of Alport syndrome

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12 December 2020

Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate

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12 December 2020

Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

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12 December 2020

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

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12 December 2020

Targeting BMP signalling in cardiovascular disease and anaemia

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12 December 2020

Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.

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TGF-β: the master regulator of fibrosis

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No longer going to waste

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12 December 2020

Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease

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12 December 2020

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

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12 December 2020

Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease

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Runx2 Deletion in Smooth muscle Cells Inhibits Vascular Osteochondrogenesis and Calcification but not Atherosclerotic Lesion Formation.

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Absolute Rates of Heart Failure, Coronary Heart Disease, and Stroke in Chronic Kidney Disease: An Analysis of 3 Community-Based Cohort Studies

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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

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12 December 2020

10.1016/J.KINT.2017.06.016

Identifiers

DOI

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28 March 2020

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28 March 2020

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