Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-β/Smad3 pathway. (Q53077318)

11 May 2018

title

Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-β/Smad3 pathway. (English)

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11 May 2018

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Xin-Zhong Huang

1

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11 May 2018

Donghai Wen

2

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Min Zhang

3

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Qionghong Xie

4

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Leting Ma

5

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11 May 2018

Yi Guan

6

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11 May 2018

Yueheng Ren

7

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11 May 2018

Jing Chen

8

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Chuan-Ming Hao

9

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11 May 2018

publication date

1 May 2014

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11 May 2018

Journal of Cellular Biochemistry

published in

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11 May 2018

volume

115

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11 May 2018

issue

5

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11 May 2018

page(s)

996-1005

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11 May 2018

Sirt1 regulates aging and resistance to oxidative stress in the heart

cites work

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SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.

21 January 2018

1 reference

Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70

21 January 2018

1 reference

Female rats fed a high-fat diet were associated with vascular dysfunction and cardiac fibrosis in the absence of overt obesity and hyperlipidemia: therapeutic potential of resveratrol

21 January 2018

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TGF-beta in kidney fibrosis: a target for gene therapy

21 January 2018

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TGF-beta signaling in renal disease

21 January 2018

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

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Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes

21 January 2018

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

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Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling

21 January 2018

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SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.

21 January 2018

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CBP/p300-mediated acetylation of histone H3 on lysine 56

21 January 2018

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

21 January 2018

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Smad3 as a mediator of the fibrotic response

21 January 2018

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Sirtuins and their relevance to the kidney.

21 January 2018

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Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

21 January 2018

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Sirt1 activation protects the mouse renal medulla from oxidative injury

21 January 2018

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Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

21 January 2018

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Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes

21 January 2018

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SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

21 January 2018

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Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3

21 January 2018

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Renal fibrosis: new insights into the pathogenesis and therapeutics

21 January 2018

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Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

21 January 2018

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Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

21 January 2018

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21 January 2018

Polyphenols and aging

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SIRT1/PGC-1: a neuroprotective axis?

21 January 2018

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Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta

21 January 2018

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Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.

21 January 2018

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NF-kappaB signaling in the aging process.

21 January 2018

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

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The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.

21 January 2018

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Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

21 January 2018

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Regulation of human SRY subcellular distribution by its acetylation/deacetylation

21 January 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

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SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

21 January 2018

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Essential role of Smad3 in angiotensin II-induced vascular fibrosis

21 January 2018

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Transforming growth factor-beta and Smad signalling in kidney diseases.

21 January 2018

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An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha

21 January 2018

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MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation

21 January 2018

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Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.24748

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11 May 2018

PubMed ID

24356887

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11 May 2018