Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease. (Q53319143)

13 May 2018

title

Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease. (English)

1 reference

13 May 2018

author name string

Israel Schechter

series ordinal

1

1 reference

13 May 2018

Etty Ziv

series ordinal

2

1 reference

13 May 2018

publication date

1 April 2011

1 reference

13 May 2018

published in

Biological Chemistry

1 reference

13 May 2018

volume

392

1 reference

13 May 2018

issue

6

1 reference

13 May 2018

page(s)

555-569

1 reference

13 May 2018

Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Emerging roles for cysteine proteases in human biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

The two sides of enzyme-substrate specificity: lessons from the aspartic proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Biosynthesis of lysosomal endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Thyroid functions of mouse cathepsins B, K, and L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Decrease in cytosolic Aspartyl-aminopeptidase but not in Alanyl-aminopeptidase activity in the frontal cortex of the aged rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Tumor suppressor gene mutations in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Cysteine cathepsins: multifunctional enzymes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Mapping of the active site of proteases in the 1960s and rational design of inhibitors/drugs in the 1990s

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Cellular mechanisms of beta-amyloid production and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Lysosomal cysteine proteases: more than scavengers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.054

21 January 2018

Identifiers

DOI

10.1515/BC.2011.054

1 reference

13 May 2018

1 reference

13 May 2018