Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. (Q53380068)

13 May 2018

title

Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. (English)

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13 May 2018

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9

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13 May 2018

author name string

Troy A Baudino

1

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13 May 2018

Kirsteen H Maclean

2

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13 May 2018

Jennifer Brennan

3

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13 May 2018

Evan Parganas

4

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13 May 2018

Chunying Yang

5

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13 May 2018

Aaron Aslanian

6

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13 May 2018

Jacqueline A Lees

7

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13 May 2018

Charles J Sherr

8

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13 May 2018

John L Cleveland

10

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13 May 2018

publication date

1 April 2003

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13 May 2018

published in

Molecular Cell

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13 May 2018

volume

11

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13 May 2018

issue

4

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13 May 2018

page(s)

905-914

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13 May 2018

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

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7 January 2021

Distinct roles for E2F proteins in cell growth control and apoptosis

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7 January 2021

The regulation of E2F by pRB-family proteins

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Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

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7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

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7 January 2021

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7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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7 January 2021

Cdc25 cell-cycle phosphatase as a target of c-myc

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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7 January 2021

Identification of CDK4 as a target of c-MYC.

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7 January 2021

Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas

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7 January 2021

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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7 January 2021

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

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7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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7 January 2021

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

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7 January 2021

Myc requires distinct E2F activities to induce S phase and apoptosis

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7 January 2021

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

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7 January 2021

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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7 January 2021

Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

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7 January 2021

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

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7 January 2021

Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

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7 January 2021

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

1 reference

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7 January 2021

Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

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7 January 2021

The Rb/E2F pathway and cancer

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7 January 2021

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

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7 January 2021

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

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7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.

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7 January 2021

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

1 reference

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7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

1 reference

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7 January 2021

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

1 reference

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7 January 2021

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

1 reference

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7 January 2021

ARF differentially modulates apoptosis induced by E2F1 and Myc.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

1 reference

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7 January 2021

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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7 January 2021

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

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7 January 2021

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Cyclin E-CDK2 is a regulator of p27Kip1.

1 reference

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7 January 2021

The INK4a/ARF network in tumour suppression

1 reference

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7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Sibling rivalry in the E2F family

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

ARF is not required for apoptosis in Rb mutant mouse embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

ARF mutation accelerates pituitary tumor development in Rb+/- mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

The E2F1-3 transcription factors are essential for cellular proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900102-3

7 January 2021

10.1016/S1097-2765(03)00102-3

Identifiers

DOI

1 reference

13 May 2018

PubMed ID

12718877

1 reference

13 May 2018