p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability. (Q53554850)

15 May 2018

title

p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability. (English)

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15 May 2018

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1

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15 May 2018

Markus Welcker

series ordinal

3

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15 May 2018

author name string

J E Grim

series ordinal

2

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15 May 2018

B E Clurman

series ordinal

4

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15 May 2018

language of work or name

English

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publication date

7 May 2007

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15 May 2018

published in

Oncogene

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15 May 2018

volume

26

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15 May 2018

page(s)

6948-6953

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15 May 2018

issue

48

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15 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210518

exact match

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cites work

Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Deregulation of cyclin E in human cells interferes with prereplication complex assembly

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Cyclin E in normal and neoplastic cell cycles

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

A mouse model for cyclin E-dependent genetic instability and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Ras activity regulates cyclin E degradation by the Fbw7 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression

21 January 2018

1 reference

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The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 January 2018

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Genetic determinants of p53-induced apoptosis and growth arrest

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Inactivation of hCDC4 can cause chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Deregulated cyclin E induces chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

Kinase-independent function of cyclin E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

inferred from DOI database lookup

7 January 2021

based on heuristic

Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210518

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210518

1 reference

15 May 2018

PubMed ID

17486057

1 reference

15 May 2018