Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. (Q53861068)

21 May 2018

title

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. (English)

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21 May 2018

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6

Morris F White

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Anita M Hennige

1

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Umut Ozcan

2

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Terumasa Okada

3

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Ulupi S Jhala

4

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21 May 2018

Markus Schubert

5

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Rohit N Kulkarni

7

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publication date

12 April 2005

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American Journal of Physiology - Endocrinology and Metabolism

published in

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volume

289

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issue

2

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page(s)

E337-46

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.

21 January 2018

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Role of brain insulin receptor in control of body weight and reproduction

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Biochemical pathways of caspase activation during apoptosis

21 January 2018

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

21 January 2018

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Evidence for a circulating islet cell growth factor in insulin-resistant states

21 January 2018

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Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

21 January 2018

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Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells

21 January 2018

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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

21 January 2018

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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

21 January 2018

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Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

21 January 2018

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

21 January 2018

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Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

21 January 2018

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

21 January 2018

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21 January 2018

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Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.

21 January 2018

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21 January 2018

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Role of endothelial cells in early pancreas and liver development

21 January 2018

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Role of VEGF-A in vascularization of pancreatic islets

21 January 2018

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Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

21 January 2018

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Insulin signal transduction and the IRS proteins

21 January 2018

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Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

21 January 2018

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

21 January 2018

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Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes

21 January 2018

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Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas

21 January 2018

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

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Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice

21 January 2018

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Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin

21 January 2018

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

21 January 2018

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Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia.

21 January 2018

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Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

21 January 2018

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Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.

21 January 2018

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Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

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Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

21 January 2018

1 reference

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10.1152/AJPENDO.00032.2004

21 January 2018

Identifiers

DOI

1 reference

21 May 2018

PubMed ID

15827066

1 reference

21 May 2018