Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. (Q54618183)

1 June 2018

title

Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. (English)

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1 June 2018

author name string

H Ogata

1

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1 June 2018

T Chinen

2

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1 June 2018

T Yoshida

3

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1 June 2018

I Kinjyo

4

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1 June 2018

G Takaesu

5

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1 June 2018

H Shiraishi

6

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1 June 2018

M Iida

7

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1 June 2018

T Kobayashi

8

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1 June 2018

A Yoshimura

9

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1 June 2018

language of work or name

English

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publication date

1 April 2006

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1 June 2018

published in

Oncogene

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1 June 2018

volume

25

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1 June 2018

page(s)

2520-2530

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1 June 2018

issue

17

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1 June 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209281

exact match

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cites work

An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group

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Chronic liver injury, TGF-beta, and cancer

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Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation

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LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

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7 January 2021

Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB.

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The role of STATs in transcriptional control and their impact on cellular function

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IL-6 induces hepatic inflammation and collagen synthesis in vivo.

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7 January 2021

SOCS3 negatively regulates IL-6 signaling in vivo

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7 January 2021

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.

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7 January 2021

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

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SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

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7 January 2021

Statins induce suppressor of cytokine signaling-3 in macrophages

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7 January 2021

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

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7 January 2021

Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

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7 January 2021

SOCS1 [corrected] inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein

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7 January 2021

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

1 reference

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7 January 2021

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

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7 January 2021

SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.

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7 January 2021

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.

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7 January 2021

Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats

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7 January 2021

Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice

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7 January 2021

Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma

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7 January 2021

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

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7 January 2021

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

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7 January 2021

Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice

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7 January 2021

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

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7 January 2021

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

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7 January 2021

Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation

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7 January 2021

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

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7 January 2021

SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition

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7 January 2021

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

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7 January 2021

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209281

7 January 2021

Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209281

7 January 2021

SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209281

7 January 2021

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209281

7 January 2021

Negative regulation of cytokine signaling and immune responses by SOCS proteins

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209281

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209281

1 reference

1 June 2018

release_hom6zws4m5hztpjog5m2ss3ibq

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hom6zws4m5hztpjog5m2ss3ibq

24 November 2022

mapped directly with Wikidata item

PubMed ID

16474852

1 reference

1 June 2018