Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease. (Q54976661)

http://europepmc.org/abstract/PMC/5994110

2 July 2018

title

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease. (English)

1 reference

http://europepmc.org/abstract/PMC/5994110

2 July 2018

author

Diana Luz Juárez-Flores

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Mario Ezquerra

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

Francisco Carmona Pontaque

3 June 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Rubén Fernández-Santiago

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

16

Glòria Garrabou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

Ingrid González-Casacuberta

3 June 2020

2

object named as

Ingrid González-Casacuberta

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

14

Francesc Cardellach

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

15

Constanza Morén

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Mariona Guitart-Mampel

7

object named as

Mariona Guitart-Mampel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

María Bañó

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Marc Catalán-García

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Juan José Rivero

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ester Tobias

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Jose Cesar Milisenda

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Eduard Tolosa

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Maria Jose Marti

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

publication date

8 June 2018

1 reference

http://europepmc.org/abstract/PMC/5994110

2 July 2018

published in

Journal of Translational Medicine

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

3 June 2020

copyright license

start time

8 June 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

The LRRK2-macroautophagy axis and its relevance to Parkinson's disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

The Role of Therapeutic Drugs on Acquired Mitochondrial Toxicity.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Comparative blood transcriptome analysis in idiopathic and LRRK2 G2019S-associated Parkinson's disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2(G2019S) carriers and in vivo.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

LRRK2 Pathways Leading to Neurodegeneration

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Cellular processes associated with LRRK2 function and dysfunction

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

The role of mitochondrial DNA mutation on neurodegenerative diseases

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Defining and measuring autophagosome flux—concept and reality

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Mitochondrial disturbances in HIV pregnancies

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

A mitocentric view of Parkinson's disease.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease?

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

The role of autophagy in neurodegenerative disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Disease duration and the integrity of the nigrostriatal system in Parkinson's disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Interplay of LRRK2 with chaperone-mediated autophagy

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Fiji: an open-source platform for biological-image analysis

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Cellular models to investigate biochemical pathways in Parkinson's disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

What genetics tells us about the causes and mechanisms of Parkinson's disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

A comparative study of Lrrk2 function in primary neuronal cultures

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Abnormal mitochondrial dynamics and neurodegenerative diseases

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Characterization of cells with different mitochondrial membrane potential during apoptosis

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Parkinson's disease: experimental models and reality

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Impaired Mitochondrial Function and Dynamics in the Pathogenesis of FXTAS.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Mitochondrial DNA disturbances and deregulated expression of oxidative phosphorylation and mitochondrial fusion proteins in sporadic inclusion body myositis

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

LRRK2 interferes with aggresome formation for autophagic clearance

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Study of oxidative, enzymatic mitochondrial respiratory chain function and apoptosis in perinatally HIV-infected pediatric patients

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

In search of an "autophagomometer".

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

A clinical, neuropsychological and olfactory evaluation of a large family with LRRK2 mutations

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5994110

High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle

13 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29884186

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S12967-018-1526-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12967-018-1526-3

Fatcat ID

release_ds3hj7bdg5fztdxlexsmitttv4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ds3hj7bdg5fztdxlexsmitttv4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29884186%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

29884186

1 reference