Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation (Q24297033)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

0 references

1 reference

mitochondrial fission

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

author name string

Yu-Chin Su

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

language of work or name

English

0 references

publication date

27 June 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

issue

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

page(s)

4545-4561

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

Cognitive, affective, and psychiatric features of Parkinson's disease

4 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondria: dynamic organelles in disease, aging, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondrial fission in apoptosis, neurodegeneration and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

A human dynamin-related protein controls the distribution of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondrial dynamics and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Reactive oxygen species: metabolism, oxidative stress, and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Drp1 phosphorylation and mitochondrial regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Allosteric modulation of Drp1 mechanoenzyme assembly and mitochondrial fission by the variable domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Asymmetric segregation of mitochondria and mortalin correlates with the multi-lineage potential of inner ear sensory cell progenitors in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Genetic animal models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

A Drosophila model for LRRK2-linked parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

The blood-brain barrier in health and chronic neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

Mitochondrial dysfunction in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

inferred from DOI database lookup

7 January 2021

based on heuristic

Description of Parkinson's disease as a clinical syndrome.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

inferred from DOI database lookup

7 January 2021

based on heuristic

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT301

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1093/HMG/DDT301

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23813973%20AND%20SRC:MED&resulttype=core&format=json