New concepts in phospholipase D signaling in inflammation and cancer. (Q55541318)

14 July 2018

1 reference

8 February 2021

New concepts in phospholipase D signaling in inflammation and cancer. (English)

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14 July 2018

main subject

inflammation

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PubMed publication ID

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28 September 2019

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26 August 2020

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8 February 2021

Julián Gómez-Cambronero

series ordinal

1

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14 July 2018

language of work or name

English

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publication date

7 July 2010

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14 July 2018

The Scientific World Journal

3 April 2019

28 September 2019

26 August 2020

8 February 2021

5 references

14 July 2018

3 April 2019

28 September 2019

26 August 2020

8 February 2021

10

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14 July 2018

page(s)

1356-1369

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14 July 2018

Creative Commons Attribution 3.0 Unported

copyright license

4 references

3 April 2019

28 September 2019

26 August 2020

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

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ScienceSource

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cites work

Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells

1 reference

12 December 2020

Role of Rho family proteins in phospholipase D activation by growth factors

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12 December 2020

Human phospholipase D1 can be tyrosine-phosphorylated in HL-60 granulocytes

1 reference

12 December 2020

Regulation of eIF-4E BP1 phosphorylation by mTOR.

1 reference

12 December 2020

Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes

1 reference

12 December 2020

Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: a mechanism for induction of chemotaxis

1 reference

12 December 2020

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

12 December 2020

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

12 December 2020

Determination of interaction sites on the small G protein RhoA for phospholipase D

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12 December 2020

Dysregulation of the TSC-mTOR pathway in human disease

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12 December 2020

Alternative phospholipase D/mTOR survival signal in human breast cancer cells

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12 December 2020

Requirement of phospholipase D1 activity in H-RasV12-induced transformation

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12 December 2020

Tyrosine phosphorylation of phospholipase D1 by v-Src does not per se result in activation

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12 December 2020

The expanding TOR signaling network

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12 December 2020

Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells

1 reference

12 December 2020

The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2.

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12 December 2020

Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability

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12 December 2020

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b

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12 December 2020

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

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12 December 2020

N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits

1 reference

12 December 2020

Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposure

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12 December 2020

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

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12 December 2020

PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis

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12 December 2020

Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells

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12 December 2020

mTOR signaling: PLD takes center stage

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12 December 2020

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

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12 December 2020

Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish

1 reference

12 December 2020

IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells

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12 December 2020

Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells

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12 December 2020

Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors).

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12 December 2020

PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation

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12 December 2020

A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation

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12 December 2020

Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling

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12 December 2020

Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2

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12 December 2020

Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts

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12 December 2020

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

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12 December 2020

Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells

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12 December 2020

Regulation of phospholipase D by phosphorylation-dependent mechanisms.

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12 December 2020

Basic fibroblast growth factor stimulates cytosolic phospholipase A2, phospholipase C-gamma1 and phospholipase D through distinguishable signaling mechanisms

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12 December 2020

Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale.

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12 December 2020

The chemokine system -- a major regulator of angiogenesis in health and disease

1 reference

12 December 2020

Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase

1 reference

12 December 2020

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1 reference

12 December 2020

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

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12 December 2020

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D.

1 reference

12 December 2020

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal

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12 December 2020

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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12 December 2020

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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12 December 2020

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

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12 December 2020

Induction of phosphatidic acid by fibroblast growth factor in cultured baby hamster kidney fibroblasts.

1 reference

12 December 2020

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

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12 December 2020

Phospholipase D: a downstream effector of ARF in granulocytes

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12 December 2020

Epidermal growth factor induces the production of biologically distinguishable diglyceride species from phosphatidylinositol and phosphatidylcholine via the independent activation of type C and type D phospholipases.

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12 December 2020

Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells

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12 December 2020

SH2/SH3 signaling proteins

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12 December 2020

Phosphatidylcholine-specific phospholipase D activity is elevated in v-Fps-transformed cells

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12 December 2020

Ras mediates the activation of phospholipase D by v-Src

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12 December 2020

Cell migration at a glance

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12 December 2020

Growing roles for the mTOR pathway

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12 December 2020

Immune cell migration in inflammation: present and future therapeutic targets

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12 December 2020

Signaling roles of diacylglycerol kinases

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12 December 2020

Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis

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12 December 2020

The elucidation of novel SH2 binding sites on PLD2

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12 December 2020

Phospholipase D couples survival and migration signals in stress response of human cancer cells

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12 December 2020

Direct modulation of phospholipase D activity by Gbetagamma

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12 December 2020

mTOR and cancer therapy

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12 December 2020

PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals

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12 December 2020

Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.

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12 December 2020

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

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12 December 2020

Regulation of mTOR by phosphatidic acid?

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12 December 2020

The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF

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12 December 2020

Ewing's sarcoma fusion protein, EWS/Fli-1 and Fli-1 protein induce PLD2 but not PLD1 gene expression by binding to an ETS domain of 5' promoter

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12 December 2020

Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR

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12 December 2020

Regulation of actin filament assembly by Arp2/3 complex and formins

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12 December 2020

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

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12 December 2020

PA promoted to manager

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12 December 2020

Defining the role of mTOR in cancer

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12 December 2020

Biochemical analysis of phospholipase D.

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12 December 2020

Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts

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12 December 2020

Anionic phospholipids, interfacial binding and the regulation of cell functions

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12 December 2020

Synthesis of the translational apparatus is regulated at the translational level

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12 December 2020

Increased activity and intranuclear expression of phospholipase D2 in human renal cancer

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12 December 2020

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

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12 December 2020

Dancing to the tune of chemokines

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12 December 2020

Regulation of translation initiation by FRAP/mTOR

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12 December 2020

Differential tyrosine phosphorylation of phospholipase D isozymes by hydrogen peroxide and the epidermal growth factor in A431 epidermoid carcinoma cells

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12 December 2020

Actin directly interacts with phospholipase D, inhibiting its activity

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12 December 2020

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

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12 December 2020

Mammalian TOR: a homeostatic ATP sensor

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12 December 2020

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

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12 December 2020

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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12 December 2020

Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2.

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12 December 2020

Molecular crosstalk between p70S6k and MAPK cell signaling pathways

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12 December 2020

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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12 December 2020

Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung

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12 December 2020

Identification of TOR signaling complexes: more TORC for the cell growth engine

1 reference

12 December 2020

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

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12 December 2020

Regulation of phospholipase D

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12 December 2020

Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling.

1 reference

12 December 2020

Identification of a JAK2-independent pathway regulating growth hormone (GH)-stimulated p44/42 mitogen-activated protein kinase activity. GH activation of Ral and phospholipase D is Src-dependent

1 reference

12 December 2020

Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae

1 reference

12 December 2020

Regulation of phospholipase D activity by actin. Actin exerts bidirectional modulation of Mammalian phospholipase D activity in a polymerization-dependent, isoform-specific manner.

1 reference

12 December 2020

Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells

1 reference

12 December 2020

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

1 reference

12 December 2020

Tor signalling in bugs, brain and brawn

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12 December 2020

Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells

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12 December 2020

Transmodulation between Phospholipase D and c-Src Enhances Cell Proliferation

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12 December 2020

Phospholipase D confers rapamycin resistance in human breast cancer cells

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12 December 2020

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

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12 December 2020

Targeting mTOR signaling for cancer therapy

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12 December 2020

Phospholipase D in cell proliferation and cancer

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12 December 2020

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

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12 December 2020

Cell migration: integrating signals from front to back

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12 December 2020

Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

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12 December 2020

Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration

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12 December 2020

Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr

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12 December 2020

Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA.

1 reference

12 December 2020

v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine

1 reference

12 December 2020

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1 reference

12 December 2020

Immunoprecipitation of a phospholipase D activity with antiphosphotyrosine antibodies

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12 December 2020

Structure and regulation of phospholipase D.

1 reference

12 December 2020

Identifiers

DOI

10.1100/TSW.2010.116

1 reference

14 July 2018

release_yndpotftvzcdvdkku67g6cxmma

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yndpotftvzcdvdkku67g6cxmma

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3070604

1 reference

14 July 2018

PubMed publication ID

20623096

1 reference

14 July 2018