Innate and adaptive immunity: specificities and signaling hierarchies revisited (Q57039670)

Innate immune recognition

Europe PubMed Central

title

Innate and adaptive immunity: specificities and signaling hierarchies revisited (English)

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Eric Vivier

1

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Bernard Malissen

object named as

Bernard Malissen

series ordinal

2

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language of work or name

English

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publication date

January 2005

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published in

Nature Immunology

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volume

6

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issue

1

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page(s)

17-21

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cites work

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Not "molecular patterns" but molecules

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Inferences, questions and possibilities in Toll-like receptor signalling

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Interplay of natural killer cells and their receptors with the adaptive immune response

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

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The specificity of TCR/pMHC interaction

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B cell positive selection: road map to the primary repertoire?

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TLR7: A new sensor of viral infection

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Structural insights into the evolution of an antibody combining site

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Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

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Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses

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Immunological memory to viral infections.

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The C-type lectin superfamily in the immune system

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Trimeric structure of a C-type mannose-binding protein

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Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil

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Therapeutics targeting the innate immune system

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Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

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Recognition of a virus-encoded ligand by a natural killer cell activation receptor

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Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

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Immunology. A pathogen receptor on natural killer cells

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Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.

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Uncertainties - discrepancies in immunology

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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

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The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation

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Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen

21 January 2018

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Signal transduction by lymphocyte antigen receptors

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Regulation of immune responses through inhibitory receptors

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Immune inhibitory receptors

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Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes

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Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future

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Autoreactivity by design: innate B and T lymphocytes

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Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

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Roles of the NKG2D immunoreceptor and its ligands

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Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis

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CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction

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B cell antigen receptor signaling 101.

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The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

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Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.

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Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

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Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo

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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

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TREM-1 amplifies inflammation and is a crucial mediator of septic shock

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Identification of a graft versus host disease-associated human minor histocompatibility antigen

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What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?

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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

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Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors

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CDR3 loop flexibility contributes to the degeneracy of TCR recognition

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An evolutionary and structural perspective on T cell antigen receptor function

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TREMs in the immune system and beyond

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Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

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The role of the DAP12 signal in mouse myeloid differentiation

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Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts.

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Selecting and maintaining a diverse T-cell repertoire

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12 December 2020

A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells

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Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells

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12 December 2020

A very high level of crossreactivity is an essential feature of the T-cell receptor

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12 December 2020